cas 142217-77-4, (1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol | Articles data ｜lookchem

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142217-77-4

Articles about 142217-77-4Total 4 be found

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Method for synthesizing Entecavir intermediate
The invention relates to a method for synthesizing an Entecavir intermediate and particularly relates to a method for synthesizing a compound represented by a formula I. According to the method, firstly, amino of 6-benzyloxy guanine is protected, and thus
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Paragraph 0031-0034

(2020/03/05)

Method for production of entecavir intermediate IV
The invention discloses a method for safe production of an entecavir intermediate IV, wherein the method includes the following contents: in a solvent, an entecavir intermediate III (N3) and benzyl guanine (Gua) undergo a reaction under a phase transfer c
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Paragraph 0013-0014; 0015-0016; 0017-0018

(2018/03/24)

BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro
BMS-200475, a never carbocyclic analog of 2'-deoxyguanosine, is a potent inhibitor of hepatitis B virus in vitro (ED50 = 3 nM) with relatively low cytotoxicity (CC50 = 21-120 μM). A practical 10-step asymmetric synthesis was developed affording BMS-200475 in 18% overall chemical yield and > 99% optical purity. The enantiomer of BMS-200475 as well as the adenine, thymine, and iodouracil analogs are much less active.
Bisacchi,Chao,Bachard,Daris,Innaimo,Jacobs,Kocy,Lapointe,Martel,Merchant,Slusarchyk,Sundeen,Young,Colonno,Zahler
p. 127 - 132
(2007/10/03)

Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
Antiviral activity is exhibited by compounds having the formula STR1 and its pharmaceutically acceptable salts.
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(2008/06/13)

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Chemical Properties

Appearance/Colour :Colorless transparent liquid
Boiling Point: 780.5 °C at 760 mmHg
Flash Point:425.8 °C
Density: 1.33 g/cm³
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
Refractive Index: 1.67
PKA: 13.88±0.70(Predicted)
PSA: 117.54000
LogP: 5.29280

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