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5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE is a nucleoside analog with a complex chemical structure. It is characterized by its 5'-O-(4,4'-dimethoxytrityl) group, which provides stability and protection during chemical synthesis, and a 3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite group, which is essential for the formation of phosphodiester bonds in the synthesis of oligonucleotides. The 5-fluorodeoxyuridine core is a modified nucleoside that has potential applications in various fields due to its unique properties.

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  • 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE

    Cas No: 142246-63-7

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  • 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE

    Cas No: 142246-63-7

  • USD $ 10.0-10.0 / Milligram

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  • 142246-63-7 Structure
  • Basic information

    1. Product Name: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE
    2. Synonyms: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE;5-FLUORO-DU CEP;5-fluorodeoxyuridine-ce*phosphoramidite for abi;5-FLUORODEOXYURIDINE-CE PHOSPHORAMIDITE FOR CYCLONE;N-blocked-5'-O-DMT CED fluorodeoxyuridine phosphoramidite;5'-DMT-5-F-2'-dU Phosphoramidite
    3. CAS NO:142246-63-7
    4. Molecular Formula: C39H46FN4O8P
    5. Molecular Weight: 748.78
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 142246-63-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Store at -20°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE(142246-63-7)
    11. EPA Substance Registry System: 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE(142246-63-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 142246-63-7(Hazardous Substances Data)

142246-63-7 Usage

Uses

Used in Pharmaceutical Industry:
5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE is used as a building block for the synthesis of oligonucleotides, which are essential in the development of new drugs and therapies. Its application in this field is due to its ability to form stable and protected phosphodiester bonds, which are crucial for the structural integrity and functionality of the synthesized oligonucleotides.
Used in Cancer Research and Treatment:
5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE is used as a potential therapeutic agent for the treatment of breast cancer. It is believed to influence the expression of HER-2, a protein that is overexpressed in certain types of breast cancer cells. By targeting this protein, the compound may help in the development of more effective treatments for breast cancer patients.
Used in Chemical Synthesis and Research:
In the field of chemical synthesis and research, 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE is used as a key intermediate in the synthesis of various nucleoside analogs and modified oligonucleotides. Its unique chemical structure allows for the exploration of new chemical reactions and the development of novel compounds with potential applications in various industries, including pharmaceuticals, diagnostics, and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 142246-63-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,2,4 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 142246-63:
(8*1)+(7*4)+(6*2)+(5*2)+(4*4)+(3*6)+(2*6)+(1*3)=107
107 % 10 = 7
So 142246-63-7 is a valid CAS Registry Number.

142246-63-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 5'-O-(4,4'-DIMETHOXYTRITYL)-5-FLUORODEOXYURIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE

1.2 Other means of identification

Product number -
Other names N-blocked-5'-O-DMT CED fluorodeoxyuridine phosphoramidite

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:142246-63-7 SDS

142246-63-7Downstream Products

142246-63-7Relevant articles and documents

ON-DEMAND PHOSPHORAMIDITE SYNTHESIS

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Page/Page column 36-38; 48, (2022/01/24)

The invention relates to a method of synthesis of phosphoramidites by immobilization of a phosphitylation agent on a resin activated to create a charged resin, then putting in contact with the charged resin with a suitable substrate. Phosphoramidites are synthesized in a few minutes from the application of the starting materials. Thus, the process makes it possible to create specific phosphoramidites on demand when they are needed in other applications. The substrates to be applied are mainly nucleosides, thus making it possible to create nucleoside phosphoramidites for the subsequent synthesis of oligonucleotides.

Aptamers Entirely Built from Therapeutic Nucleoside Analogues for Targeted Cancer Therapy

Ma, Yuan,Yang, Jiapei,Zhang, Chuan,Zhu, Lijuan,Zhu, Xinyuan

supporting information, p. 1493 - 1497 (2022/02/10)

Owing to the specific and high binding affinity of aptamers to their targets, aptamer-drug conjugates (ApDCs) have emerged as a promising drug delivery system for targeted cancer therapy. However, in a conventional ApDC, the aptamer segment usually just s

Enhancing antitumor efficacy of nucleoside analog 5-fluorodeoxyuridine on her2-overexpressing breast cancer by affibody-engineered DNA nanoparticle

Chen, Shengxi,Du, Jie,Han, Mengnan,Li, Wei,Yang, Xueli,Zhang, Chao,Zhang, Fanghua,Zhang, Honglei

, p. 885 - 900 (2020/02/18)

Background: Chemotherapy, as an adjuvant treatment strategy for HER2-positive breast cancer, can effectively improve clinical symptoms and overcome the drug resistance of therapeutic monoclonal antibodies. Nucleoside analogues are a class of traditional c

THERAPEUTIC NANOCONJUGATES AND USES THEREOF

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Page/Page column 65, (2019/01/30)

The present invention relates to nanostructured conjugates, more specifically to nanostructured fusion proteins suitable for the selective delivery of their conjugated therapeutic agents to specific cell and tissue types. It also relates to nanoparticles comprising such nanostructured proteins and the therapeutic uses thereof.

Floxuridine Homomeric Oligonucleotides “Hitchhike” with Albumin In Situ for Cancer Chemotherapy

Jin, Cheng,Zhang, Hui,Zou, Jianmei,Liu, Yan,Zhang, Lin,Li, Fengjie,Wang, Ruowen,Xuan, Wenjing,Ye, Mao,Tan, Weihong

supporting information, p. 8994 - 8997 (2018/07/25)

Automated attachment of chemotherapeutic drugs to oligonucleotides through phosphoramidite chemistry and DNA synthesis has emerged as a powerful technology in constructing structure-defined and payload-tunable oligonucleotide–drug conjugates. In practice,

DNA Trojan Horses: Self-Assembled Floxuridine-Containing DNA Polyhedra for Cancer Therapy

Mou, Quanbing,Ma, Yuan,Pan, Gaifang,Xue, Bai,Yan, Deyue,Zhang, Chuan,Zhu, Xinyuan

supporting information, p. 12528 - 12532 (2017/09/12)

Based on their structural similarity to natural nucleobases, nucleoside analogue therapeutics were integrated into DNA strands through conventional solid-phase synthesis. By elaborately designing their sequences, floxuridine-integrated DNA strands were sy

Fluorine at the C5 Position of 2′-Deoxyuridine Enhances Repair of a O4-Methyl Adduct by O6-Alkylguanine DNA Alkyltransferases

Sacre, Lauralicia,Wilds, Christopher J.

, p. 3003 - 3008 (2017/06/06)

Alkylation damage at the O6- and O4-atoms of 2′-deoxyguanosine (dG) and thymidine (T), respectively, can be removed by O6-alkylguanine-DNA alkyltransferases (AGTs). Previous studies have shown that human AGT (hAGT) repairs

Preparation of oligomeric 2'-deoxy-5-fluorouridylate of defined length and backbone composition: A novel pro-drug form of the potent anti-cancer drug 2'-deoxy-5-fluorouridylate

Gmeiner,Sahasrabudhe,Pon,Sonntag,Srinivasan,Iversen

, p. 243 - 253 (2007/10/02)

A recursive protection scheme for FdUMP is employed by synthesizing oligonucleotides consisting of only FdU. 3'-O-exonuclease action releases FdUMP and a shortened oligonucleotide from which further exonuclease action releases more FdUMP. Such oligonucleo

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