124482-92-4

Basic information

• Product Name: 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine
• Synonyms: 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine
• CAS NO: 124482-92-4
• Molecular Weight: 236.681
• Mol File: 124482-92-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine(124482-92-4)
• EPA Substance Registry System: 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine(124482-92-4)

Safety Data

• Hazardous Substances Data: 124482-92-4(Hazardous Substances Data)

Upstream product

• 76101-30-9 2-cyanoethyl phosphorodichloridite 
• 108-18-9 diisopropylamine 
• 17425-88-6 N,N-diisopropyl-1,1,1-trimethylsilylamine 
• 109-78-4 3-Hydroxypropionitrile 
• 921-26-6 N,N-diisopropylphosphoramide dichloride 

Downstream Products

• 149624-87-3 N⁶-<<1-(4-Methoxytriphenylmethyl)imidazol-4-yl>acetyl>-6-aminohexyl-2-cyanoethyl N,N-diisopropylphosphoramidite 
• 157543-67-4 5'-O-(4,4'-dimethoxytrityl)-N-acetyl-2'-deoxycytidine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite 
• 148493-99-6 Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(2-benzoylamino-5-methyl-4-oxo-4H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 122591-37-1 5'-O-monomethoxytritylarabinouridine-3'-O-acetyl-2'-O-N,N-diisopropyl-β-cyanoethylphosphoramidite 
• 112475-39-5 5'-O-monomethoxytritylarabinouridine-2'-O-acetyl-3'-O-N,N-diisopropyl-β-cyanoethylphosphoramidite 
• 115383-35-2 N⁴-benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)cytidine 5'-O-(β-cyanoethyl N,N-diisopropylphosphoramidite) 
• 146578-16-7 C₅₈H₆₈N₁₀O₁₃P₂ 
• 143970-95-0 C₅₈H₆₅N₆O₁₅P 
• 145744-02-1 C₆₁H₈₂N₈O₉P₂Si 
• 147490-80-0 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-2-N-(phenylacetyl)-5'-O-(9-phenylxanthen-9-yl)guanosine 3'-<(2-cyanoethyl)-N,N-diisopropylphosphoroamidite> 
• 147490-78-6 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-5'-O-(9-phenylxanthen-9-yl)-6-N-pivaloyladenosine 3'-<(2-cyanoethyl)-N,N-diisopropylphosphoroamidite> 
• 147490-79-7 4-N-benzoyl-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-5'-O-(9-phenylxanthen-9-yl)cytidine 3'-<(2-cyanoethyl)-N,N-diisopropylphosphoroamidite> 
• 143417-17-8 C₅₆H₆₆N₇O₇PSi 
• 147490-81-1 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-5'-O-(9-phenylxanthen-9-yl)uridine 3'-<(2-cyanoethyl)-N,N-diisopropylphosphoroamidite> 

Relevant articles and documents

Synthesis of nucleoside mono-, di-, and triphosphoramidates from solid-phase cyc/osaligenyl phosphitylating reagents

Chloromethyl polystyrene resin was reacted with 5-hydroxysalicylaldehyde in the presence of potassium carbonate to afford polymer-bound 2-hydroxybenzaldehyde. Subsequent reduction with borane solution produced polymer-bound 2-hydroxybenzyl alcohol. The re

Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase

Five analogs of cyclic di-nucleotidic acid including c-di-GMP were synthesized and evaluated for their biological activities on Slr1143, a diguanylate cyclase of Synechocystis sp. Slr1143 was overexpressed from the recombinant plasmid which contained the gene of interest and subsequently purified by affinity chromatography. A new HPLC method capable of separating the compound and product peaks with good resolution was optimized and applied to the analysis of the compounds. Results obtained show that cyclic di-inosinylic acid 1b demonstrates a stronger inhibition on Slr1143 than c-di-GMP and is a potential inhibitor for biofilm formation.

Solid-phase synthesis of symmetrical 5′,5′-dinucleoside mono-, di-, tri-, and tetraphosphodiesters

(Chemical Equation Presented) Four classes of phosphitylating reagents were subjected to reactions with aminomethyl polystyrene resin-bound p-acetoxybenzyl alcohol to yield the corresponding polymer-bound mono-, di-, tri-, and tetraphosphitylating reagents. The solid-phase reagents were reacted with unprotected nucleosides (e.g., thymidine, adenosine, 3′-azido-3′- deoxythymidine, cytidine, or inosine) in the presence of 5-(ethylthio)-1H- tetrazole. Polymer-bound nucleosides underwent oxidation with fert-butyl hydroperoxide, deprotection of cyanoethoxy groups with DBU, and the acidic cleavage, respectively, to afford 5′,5′-dinucleoside mono-, di-, tri-, and tetraphosphodiesters in 59-78% yield.