Is NMR fragment screening fine-tuned to assess druggability of protein-protein interactions?
Modulation of protein-protein interactions (PPIs) with small molecules has been hampered by a lack of lucid methods capable of reliably identifying high-quality hits. In fragment screening, the low ligand efficiencies associated with PPI target sites pose
Dias, David M.,Van Molle, Inge,Baud, Matthias G. J.,Galdeano, Carles,Geraldes, Carlos F. G. C.,Ciulli, Alessio
p. 23 - 28
(2014/02/14)
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