Anticonvulsant evaluation and mechanism of action of benzylamino enaminones
The mechanism of anticonvulsant action was evaluated for the benzylamino enaminones. The most potent enaminone in this series was the unsubstituted benzylamine analog (30; methyl 4-benzylamino-6-methyl-2-oxocyclohex-3-en-1-oate) which had an oral effective dose (ED50) in rats of 27 mg/kg against maximal electroshock seizures, and a concentration 10-fold less than this dose depressed excitatory synaptic transmission, and action potential firing in the rat brain in vitro.
Edafiogho, Ivan O.,Ananthalakshmi, Kethireddy V.V.,Kombian, Samuel B.
p. 5266 - 5272
(2007/10/03)
Synthesis and anticonvulsant activity of enaminones
A new series of novel enaminones has been synthesized from cyclic β- dicarbonyl precursors which were condensed with morpholine, pyrrolidine, phenethylamine, hydrazines, substituted benzyl amines, and substituted anilines. These compounds were subsequentl