14256-99-6

Basic information

• Product Name: 4,6-Dihydroxy-5-formylpyrimidine
• Synonyms: 4,6-DIHYDROXY-5-FORMYLPYRIMIDINE;5-Pyrimidinecarboxaldehyde, 1,4-dihydro-6-hydroxy-4-oxo- (9CI);(5E)-5-(Hydroxymethylidene)-1H-pyrimidine-4,6-dione;1,4-Dihydro-6-hydroxy-4-oxo-5-pyrimidinecarboxaldehyde
• CAS NO: 14256-99-6
• Molecular Formula: C5H4N2O3
• Molecular Weight: 140.1
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 14256-99-6.mol

Chemical Properties

• Appearance: /
• Density: 1.63g/cm3
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4,6-Dihydroxy-5-formylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Dihydroxy-5-formylpyrimidine(14256-99-6)
• EPA Substance Registry System: 4,6-Dihydroxy-5-formylpyrimidine(14256-99-6)

Safety Data

• Hazardous Substances Data: 14256-99-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4,6-Dihydroxy-5-formylpyrimidine is used as an intermediate in the synthesis of various pharmaceuticals. Its role in the production of thiamine and related compounds contributes to the development of treatments for thiamine deficiency and associated disorders. 4,6-Dihydroxy-5-formylpyrimidine's potential therapeutic applications extend to the enhancement of health and well-being by addressing vitamin deficiencies.
Used in Agrochemical Industry:
In the agrochemical sector, 4,6-Dihydroxy-5-formylpyrimidine serves as a precursor in the synthesis of certain agrochemicals. Its use in this industry aids in the development of products that can improve crop yields and protect plants from diseases, thereby contributing to sustainable agriculture and food security.
Used in Vitamin B1 Biosynthesis:
4,6-Dihydroxy-5-formylpyrimidine is utilized as a key intermediate in the biosynthesis of thiamine (vitamin B1) in organisms. This application is crucial for maintaining the metabolic processes that rely on thiamine, ensuring the proper functioning of biological systems in plants and microorganisms.
Used in Research and Development:
4,6-Dihydroxy-5-formylpyrimidine is also used in research and development settings to study the biochemical processes related to thiamine metabolism. Understanding the role of 4,6-Dihydroxy-5-formylpyrimidine in these processes can lead to advancements in the fields of biochemistry and medicine, potentially uncovering new therapeutic targets and applications.

Upstream product

• 15263-75-9 N-((4,6-dihydroxypyrimidin-5-yl)methylene)-N-methylmethylammonium chloride salt 

Downstream Products

• 59025-32-0 5-aminomethylenebarbituric acid 
• 5305-40-8 2,6-dichloro-pyrimidine carbaldehyde 

Relevant articles and documents

Method for synthesizing 4,6-dichloropyrimidine-5-carbonitrile

The invention relates to a method for synthesizing a compound 4,6-dichloropyrimidine-5-carbonitrile. The method has the advantages of mild reaction conditions, environmental protection, easiness in preservation of an intermediate, and convenience for large-scale production.

Studies of Azoles and Azines. CI. Reaction of 4,6-Dihydroxypyrimidine and Barbituric Acid with 4,6-Dihydroxypyrimidine-5-carbaldehyde

Reaction of barbituric acid with 4,6-dihydroxypyrimidine-5-carbaldehyde in water at 20-60°C yields 5-(4,6-dihydroxypyrimidin-5-ylmethylene)barbituric acid. The same reaction performed in acetic acid at 120°C yields 5-aminomethylenebarbituric acid. One of the pyrimidine rings also opens in the reaction of 4,6-dihydroxypyrimidine with 4,6-dihydroxypyrimidine-5-carbaldehyde, which yields pyrano[2,3-d]pyrimidine-6-carboxamide derivatives.