- A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase
-
Glycosyltransferases (GTs) comprise a prominent family of enzymes that play critical roles in a variety of cellular processes, including cell signaling, cell development, and host-pathogen interactions. Glycosyl transfer can proceed with either inversion
- Albesa-Jov, David,Mendoza, Fernanda,Rodrigo-Unzueta, Ane,Gomolln-Bel, Fernando,Cifuente, Javier O.,Urresti, Saioa,Comino, Natalia,Gmez, Hansel,Romero-Garca, Javier,Lluch, Jos M.,Sancho-Vaello, Enea,Biarns, Xevi,Planas, Antoni,Merino, Pedro,Masgrau, Laura,Guerin, Marcelo E.
-
supporting information
p. 9898 - 9902
(2015/08/19)
-
- Orthogonally protected glycerols and 2-aminodiols: Useful building blocks in heterocyclic chemistry
-
The efficient synthesis of orthogonally protected glycerols, 2-aminopropane-1,3-diols and 2-aminobutane-1,4-diols that can constitute useful tools in heterocyclic chemistry, is reported. These interesting tri-functionalized small synthons were easily prepared from serine or aspartic acid. In addition, these substrates can be readily transformed into their iodide derivatives in very good yields. ARKAT USA, Inc.
- Ollivier, Anthony,Goubert, Marlene,Tursun, Ahmatjan,Canet, Isabelle,Sinibaldia, Marie-Eve
-
scheme or table
p. 108 - 126
(2010/10/03)
-
- Synthesis of potassium (2R)-2-O-α-d-glucopyranosyl-(1→6)-α-d-glucopyranosyl-2,3-dihydroxypropanoate a natural compatible solute
-
Ethyl 6-O-acetyl-2,3,4-tribenzyl-1-thio-d-glucopyranoside, as a mixture of anomers, was employed for the stereoselective synthesis of the potassium salt of (2R)-2-O-α-d-glucopyranosyl-(1→6)-α-d-glucopyranosyl-2,3-dihydroxypropanoic acid (α-d-glucosyl-(1→6
- Lourenco, Eva C.,Maycock, Christopher D.,Rita Ventura
-
experimental part
p. 2073 - 2078
(2010/03/01)
-
- Synthetic studies towards 4,10-diaza-1,7-dioxaspiro[5.5]undecanes: access to 3-aza-6,8-dioxabicyclo[3.2.1]octan-2-one and 2H-1,4-oxazin-3(4H)-one frameworks
-
Synthetic approaches towards 4,10-diaza-1,7-dioxaspiro[5.5]undecanes starting from 1,3-dichloroacetone and solketal derivatives are explored. The method relies on the preparation of a key bis-substituted dihydroxy-protected oxime, which would undergo a final acidic deprotection-spiroacetalization process. Although the desired diazaspiroketal framework could not be obtained, our conditions led to the unexpected 3-aza-6,8-dioxabicyclo[3.2.1]octan-2-one 18 or to the oxazinone 32 in good yields.
- Goubert, Marlène,Toupet, Lo?c,Sinibaldi, Marie-Eve,Canet, Isabelle
-
p. 8255 - 8266
(2008/02/08)
-
- Stereochemical assignment of the C1-C6 fragment of psymberin by synthesis and natural product degradation
-
(Chemical Equation Presented) Psymberin is a sponge-derived natural product that shows striking selectivity as a cytotoxic agent. Conformational mobility has precluded stereochemical assignment for the acyl fragment of this molecule (psymberic acid) by NM
- Green, Michael E.,Rech, Jason C.,Floreancig, Paul E.
-
p. 4117 - 4120
(2007/10/03)
-
- Antiviral and Antitumor Structure-Activity Relationship Studies on Tetracyclic Eudistomines
-
The in vitro antiviral and antitumor activities of (-)-debromoeudistomin K (1a) and 10 structural analogues (1b-1j and 11) were evaluated.The synthesis was accomplished with an intramolecular Pictet-Spengler condensation reaction as the key step.This exam
- Maarseveen, Jan H. Van,Hermkens, Pedro H. H.,Clercq, Erik De,Balzarini, Jan,Scheeren, Hans W.,Kruse, Chris G.
-
p. 3223 - 3230
(2007/10/02)
-