- Ruthenium-Catalyzed Enantioselective Hydrogenation of 1,8-Naphthyridine Derivatives
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The first asymmetric hydrogenation of 2,7-disubstituted 1,8-naphthyridines catalyzed by chiral cationic ruthenium diamine complexes has been developed. A wide range of 1,8-naphthyridine derivatives were effectively hydrogenated to give 1,2,3,4-tetrahydro-1,8-naphthyridines with up to 99% ee and full conversions. The method provides a practical and facile approach to the preparation of valuable chiral heterocyclic building blocks and useful motifs for a new kind of P,N-ligand.
- Ma, Wenpeng,Chen, Fei,Liu, Youran,He, Yan-Mei,Fan, Qing-Hua
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- A four-hydrogenated 1, 8 - naphthyridine apperception composition preparation method and its prepared chiral products
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The invention discloses a preparation method of a tetrahydro 1, 8-naphthyridine compound. The preparation method comprises the following steps: under the existence of a chiral catalyst, enabling a compound with the structure shown in the formula (1) (in the description) and hydrogen to be subjected to addition reaction, wherein the chiral catalyst is a coordination compound with the structure shown in the formula (2) (in the description). The invention further provides a chiral product of the tetrahydro 1, 8-naphthyridine compound, prepared through the preparation method. According to the invention, the proper compound with the structure shown in the formula (1) (in the description) is used as a substrate, and the proper coordination compound with the structure shown in the formula (2) (in the description) is used as the chiral catalyst to perform selective hydrogenation reduction on 1, 8-naphthyridine compound with the structure shown in the formula (1) by adopting hydrogen, so that the chiral product of the tetrahydro 1, 8-naphthyridine compound is prepared with low cost. The chiral product of the tetrahydro 1, 8-naphthyridine compound can be used as a biologically active compound and a structural building block of a chiral drug.
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Paragraph 0242; 0243; 0244; 0251; 0252; 0253
(2018/03/26)
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- Suzuki-miyaura reactions of 2,7-dichloro-1,8-naphthyridine
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2,7-Diaryl- and 2,7-dialkenyl-1,8-naphthyridines were prepared in high yields by Suzuki-Miyaura reactions of 2,7-dichloro-1,8-naphthyridines. While most of the products proved to be not or only weakly fluorescent, we observed a strong fluorescence in case of 2,7-bis(4-methoxyphenyl)-1,8-naphthyridine containing two electron-donating aryl groups. Georg Thieme Verlag Stuttgart - New York.
- Ehlers, Peter,Petrosyan, Andranik,Ghochikyan, Tariel V.,Saghyan, Ashot S.,Neubauer, Antje,Lochbrunner, Stefan,Langer, Peter
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p. 359 - 362
(2013/04/10)
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