142685-25-4Relevant articles and documents
In situ monitoring of bindings between dasatinib and its target protein kinases using magnetic nanoparticles in live cells
Kim, Dae-Joong,Yi, Yong-Weon,Jin, Hwan Kim
, p. 16466 - 16467 (2008)
We report a novel technology, called In Cell IT, for in situ monitoring of bindings between a small molecule kinase inhibitor and its target protein kinases in live cells using a kinase inhibitor, dasatinib, as a model compound. Streptavidin-attached MNPs were coated by biotinylated dasatinib, and then these dasatinib-MNPs were transferred into cells. In the cells, the MNPs were aligned to the same direction of the magnetic field and EGFP-tagged target protein kinases were bound to dasatinib-MNPs. Using this technology, we demonstrated the bindings between dasatinib and its target protein kinases including SRC, ABL1, and CSK in live cells. The specificity of these bindings was also confirmed by cold competition using unbiotinylated dasatinib in the same cells. Copyright
POLYBIOTIN COMPOUNDS FOR MAGNETIC RESONANCE IMAGINING AND DRUG DELIVERY
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Page/Page column 71; 72, (2008/06/13)
The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is a gadolinium. Another aspect of the invention relates to a compound comprising three biotin moieties and a pharmaceutical agent covalently bound to a heterocyclic core. In certain embodiments, the pharmaceutical agent is an antibiotic, antiviral, or radionuclide. Another aspect of the present invention relates to a method of treating disease involving administering the compounds of the invention to a mammal. Another aspect of the present invention relates to a method of acquiring a magnetic resonance image using the compounds of the invention.
Bifunctional Crosslinking oligonucleotides adapted for linking to a target sequence of duplex DNA
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, (2008/06/13)
Chemically modified oligonucleotides (ODNS) are complementary, either in the sense of the classic “four letter code” recognition motif, or in the sense required for triple strand formation based on the more limited “two letter code recognition motif”, to
Synthesis of [18F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide], a marker for PET detection of hypoxia
Josse, Olivier,Labar, Daniel,Georges, Benoit,Grégoire, Vincent,Marchand-Brynaert, Jacqueline
, p. 665 - 675 (2007/10/03)
[18F]-2-(2-Nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide ([18F]-EF3) has been prepared, in 65% chemical yield and 5% radiochemical yield, by coupling 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1-yl) acetate 1 with [18F]-3,3,3-trifluoropropylamine 7. This original radiolabelled key-synthon was obtained in 40% overall chemical yield by oxidative [18F]-fluorodesulfurization of ethyl N-phthalimido-3-aminopropane dithioate 4, followed by deprotection with hydrazine of the resulting [18F]-N-phthalimido-3,3,3-trifluoropropylamine 5. All the process was performed within 90min, from the [18F]-HF production in the cyclotron to the purification of the final target. Copyright
Selective binding complementary oligonucleotides
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, (2008/06/13)
In a matched pair of oligonucleotides (ODNS) each member of the pair is complementary or substantially complementary in the Watson Crick sense to a target sequence of duplex nucleic acid where the two strands of the target sequence are themselves compleme
Solid support for synthesis of 3'-tailed oligonucleotides
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, (2008/06/13)
A solid support for oligonucleotide synthesis has the structure STR1 where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytri