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2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE is an organofluorine chemical compound with the molecular formula C8H2F7O2. It features a phenyl ring with four fluorine atoms and an acetyl group with three fluorine atoms. This colorless liquid has a pungent odor and is recognized for its high reactivity.

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  • 142685-25-4 Structure
  • Basic information

    1. Product Name: 2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE
    2. Synonyms: 2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE;2,3,5,6-Tetrafluorophenyl trifluoroacetate 98%;2,3,5,6-Tetrafluorophenyltrifluoroacetate98%;Trifluoroacetic acid 2,3,5,6-tetrafluorophenyl ester, 2,3,5,6-Tetrafluorophenyl 2,2,2-trifluoroethanoate;2,3,5,6-Tetrafluorophenyl 2,2,2-trifluoroacetate
    3. CAS NO:142685-25-4
    4. Molecular Formula: C8HF7O2
    5. Molecular Weight: 262.08
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 142685-25-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 145.996°C at 760 mmHg
    3. Flash Point: 41.681°C
    4. Appearance: /
    5. Density: 1.635g/cm3
    6. Vapor Pressure: 4.734mmHg at 25°C
    7. Refractive Index: 1.39
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: 2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE(142685-25-4)
    12. EPA Substance Registry System: 2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE(142685-25-4)
  • Safety Data

    1. Hazard Codes: C
    2. Statements: 36/37/38
    3. Safety Statements: 26-36/37/39
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 142685-25-4(Hazardous Substances Data)

142685-25-4 Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used as a Solvent in Organic Reactions:
In the chemical industry, 2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE serves as a solvent for organic reactions, facilitating specific chemical processes and improving the efficiency of certain syntheses.
Used as a Reagent in Fluorination Processes:
2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE is utilized as a reagent in the fluorination of organic compounds, enabling the introduction of fluorine atoms into molecules, which can significantly alter their properties and reactivity.
Safety Note:
Due to its high reactivity, 2,3,5,6-TETRAFLUOROPHENYL TRIFLUOROACETATE should be handled with caution. It has the potential to cause skin and eye irritation, and appropriate safety measures should be taken during its use.

Check Digit Verification of cas no

The CAS Registry Mumber 142685-25-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,6,8 and 5 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 142685-25:
(8*1)+(7*4)+(6*2)+(5*6)+(4*8)+(3*5)+(2*2)+(1*5)=134
134 % 10 = 4
So 142685-25-4 is a valid CAS Registry Number.
InChI:InChI=1/C8HF7O2/c9-2-1-3(10)5(12)6(4(2)11)17-7(16)8(13,14)15/h1H

142685-25-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (2,3,5,6-tetrafluorophenyl) 2,2,2-trifluoroacetate

1.2 Other means of identification

Product number -
Other names 2,3,5,6-tetrafluorophenyl 2,2,2-trifluoroacetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:142685-25-4 SDS

142685-25-4Relevant articles and documents

In situ monitoring of bindings between dasatinib and its target protein kinases using magnetic nanoparticles in live cells

Kim, Dae-Joong,Yi, Yong-Weon,Jin, Hwan Kim

, p. 16466 - 16467 (2008)

We report a novel technology, called In Cell IT, for in situ monitoring of bindings between a small molecule kinase inhibitor and its target protein kinases in live cells using a kinase inhibitor, dasatinib, as a model compound. Streptavidin-attached MNPs were coated by biotinylated dasatinib, and then these dasatinib-MNPs were transferred into cells. In the cells, the MNPs were aligned to the same direction of the magnetic field and EGFP-tagged target protein kinases were bound to dasatinib-MNPs. Using this technology, we demonstrated the bindings between dasatinib and its target protein kinases including SRC, ABL1, and CSK in live cells. The specificity of these bindings was also confirmed by cold competition using unbiotinylated dasatinib in the same cells. Copyright

POLYBIOTIN COMPOUNDS FOR MAGNETIC RESONANCE IMAGINING AND DRUG DELIVERY

-

Page/Page column 71; 72, (2008/06/13)

The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is a gadolinium. Another aspect of the invention relates to a compound comprising three biotin moieties and a pharmaceutical agent covalently bound to a heterocyclic core. In certain embodiments, the pharmaceutical agent is an antibiotic, antiviral, or radionuclide. Another aspect of the present invention relates to a method of treating disease involving administering the compounds of the invention to a mammal. Another aspect of the present invention relates to a method of acquiring a magnetic resonance image using the compounds of the invention.

Bifunctional Crosslinking oligonucleotides adapted for linking to a target sequence of duplex DNA

-

, (2008/06/13)

Chemically modified oligonucleotides (ODNS) are complementary, either in the sense of the classic “four letter code” recognition motif, or in the sense required for triple strand formation based on the more limited “two letter code recognition motif”, to

Synthesis of [18F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide], a marker for PET detection of hypoxia

Josse, Olivier,Labar, Daniel,Georges, Benoit,Grégoire, Vincent,Marchand-Brynaert, Jacqueline

, p. 665 - 675 (2007/10/03)

[18F]-2-(2-Nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide ([18F]-EF3) has been prepared, in 65% chemical yield and 5% radiochemical yield, by coupling 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1-yl) acetate 1 with [18F]-3,3,3-trifluoropropylamine 7. This original radiolabelled key-synthon was obtained in 40% overall chemical yield by oxidative [18F]-fluorodesulfurization of ethyl N-phthalimido-3-aminopropane dithioate 4, followed by deprotection with hydrazine of the resulting [18F]-N-phthalimido-3,3,3-trifluoropropylamine 5. All the process was performed within 90min, from the [18F]-HF production in the cyclotron to the purification of the final target. Copyright

Selective binding complementary oligonucleotides

-

, (2008/06/13)

In a matched pair of oligonucleotides (ODNS) each member of the pair is complementary or substantially complementary in the Watson Crick sense to a target sequence of duplex nucleic acid where the two strands of the target sequence are themselves compleme

Solid support for synthesis of 3'-tailed oligonucleotides

-

, (2008/06/13)

A solid support for oligonucleotide synthesis has the structure STR1 where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytri

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