199734-70-8Relevant academic research and scientific papers
A simplified synthesis of 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1-yl) acetate
Wilson, Hanna
, p. 511 - 513 (2003)
2,3,5,6-Tetrafluorophenyl 2-(2-nitroimidazol-1-yl) acetate has been synthesized via an improved route which involves the direct coupling of 2-(2-nitroimidazol-1-yl) acetic acid with 2,3,5,6-tetrafluorophenol. Copyright
Synthesis of [18F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide], a marker for PET detection of hypoxia
Josse, Olivier,Labar, Daniel,Georges, Benoit,Grégoire, Vincent,Marchand-Brynaert, Jacqueline
, p. 665 - 675 (2007/10/03)
[18F]-2-(2-Nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide ([18F]-EF3) has been prepared, in 65% chemical yield and 5% radiochemical yield, by coupling 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1-yl) acetate 1 with [18F]-3,3,3-trifluoropropylamine 7. This original radiolabelled key-synthon was obtained in 40% overall chemical yield by oxidative [18F]-fluorodesulfurization of ethyl N-phthalimido-3-aminopropane dithioate 4, followed by deprotection with hydrazine of the resulting [18F]-N-phthalimido-3,3,3-trifluoropropylamine 5. All the process was performed within 90min, from the [18F]-HF production in the cyclotron to the purification of the final target. Copyright
