142720-24-9 Usage
Uses
Used in Pharmaceutical Industry:
FGIN-1-27 is used as a pharmaceutical compound for its potent inositol monophosphatase inhibitory properties. It is particularly valuable in the development of treatments for various medical conditions, as its inhibition of inositol monophosphatase can have significant effects on cellular processes and signaling pathways.
Used in Research Applications:
In the field of scientific research, FGIN-1-27 is used as a research tool to study the role of inositol monophosphatase in cellular functions and disease mechanisms. Its ability to inhibit this enzyme allows researchers to gain insights into the underlying processes and potential therapeutic targets for various diseases.
Used in Drug Development:
FGIN-1-27 is also utilized in the development of new drugs targeting inositol monophosphatase. Its potent inhibitory action makes it a promising candidate for the creation of novel therapeutic agents that can potentially treat a range of conditions related to the dysregulation of inositol monophosphatase.
Biological Activity
Binds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC 50 = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation.
Check Digit Verification of cas no
The CAS Registry Mumber 142720-24-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,7,2 and 0 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 142720-24:
(8*1)+(7*4)+(6*2)+(5*7)+(4*2)+(3*0)+(2*2)+(1*4)=99
99 % 10 = 9
So 142720-24-9 is a valid CAS Registry Number.
InChI:InChI=1/C28H37FN2O/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)21-25-24-13-9-10-14-26(24)30-28(25)22-15-17-23(29)18-16-22/h9-10,13-18,30H,3-8,11-12,19-21H2,1-2H3
142720-24-9Relevant articles and documents
Preparation of indoles from α-aminonitriles: A short synthesis of FGIN-1-27
Opatz, Till,Ferenc, Dorota
, p. 4473 - 4475 (2007/10/03)
α-Aminonitriles derived from 2-aminocinnamic acid esters and amides can be cyclized under basic conditions to furnish substituted indole-3-acetic acid derivatives in quantitative yield. The reaction provides a simple access to a class of biologically acti
Chemistry, Binding Affinities, and Behavioral Properties of a New Class of "Antineophobic" Mitochondrial DBI Receptor Complex (mDRC) Ligands
Kozikowski, A. P.,Ma, D.,Brewer, James,Sun, S.,Costa, E.,et al.
, p. 2908 - 2920 (2007/10/02)
The mitochondrial DBI receptor complex (mDRC; previously called the peripheral benzodiazepine receptors) is linked to the production of neurosteroids such as pregnenolone sulfate, dehydroepiandrosterone sulfate, and others.In order to gain further informa
