143-16-8Relevant articles and documents
Hydroaminomethylation of olefins using a rhodium carbene catalyst
Seayad, Abdul Majeed,Selvakumar, Kumaravel,Ahmed, Moballigh,Beller, Matthias
, p. 1679 - 1683 (2003)
Hydroaminomethylation of terminal as well as internal aliphatic and aromatic olefins with various amines is described in the presence of [Rh(cod)(Imes)Cl] as a catalyst. In general good to excellent yields and high chemoselectivity were obtained in THF at 85-105°C using 0.1 mol% of catalyst.
CO2-tuned highly selective reduction of formamides to the corresponding methylamines
Chao, Jianbin,Guo, Zhiqiang,Pang, Tengfei,Wei, Xuehong,Xi, Chanjuan,Yan, Leilei
supporting information, p. 7534 - 7538 (2021/10/12)
We herein describe an efficient, CO2-tuned and highly selective C-O bond cleavage of N-methylated formanilides. With easy-to-handle and commercially available NaBH4 as the reductant, a variety of formanilides could be turned into the desired tertiary amines in moderate to excellent yields. The role of CO2 has been investigated in detail, and the mechanism is proposed on the basis of experiments.
Catalyst Evolution in Ruthenium-Catalyzed Coupling of Amines and Alcohols
Cherepakhin, Valeriy,Williams, Travis J.
, p. 56 - 65 (2019/12/12)
We describe the mechanism, scope, and catalyst evolution for our ruthenium-based coupling of amines and alcohols, which proceeds from a [(η6-cymene)RuCl(PyCH2PtBu2)]OTf (1) precatalyst. The method selectively produces secondary amines through a hydrogen borrowing mechanism and is successfully applied to several heterocyclic carbinol substrates. Under the reaction conditions, precatalyst 1 evolves through a series of catalytic intermediates: [(η6-cymene)RuH(PyCH2PtBu2)]OTf (3), [Ru3H2Cl2(CO)(PyCH2PtBu2)2{μ-(C5H3N)CH2PtBu2}]OTf (4), and a diastereomeric pair of [Ru2HCl(CO)2(PyCH2PtBu2)2(μ-O2CnPr)]X (trans-5, X = Cl; cis-6, X = OTf). The structures of 4 and 6 were established by single-crystal X-ray diffraction. A study of catalytic activity shows that 4 is a dormant (but alive) form of the catalyst, whereas 5 and 6 are the ultimate dead forms. Electrochemical studies show that 4 is redox active and undergoes electrochemically reversible one-electron oxidation at E1/2 = 0.442 V (vs Fc+/Fc) in CH2Cl2 solution. We discuss the factors that govern the formation of 3-6 and the role of selective ruthenium carbonylation, which is essential for enabling generation of the active catalyst. We also connect these discoveries to the identification of conditions for amination of aliphatic alcohols, which eluded us until we understood the catalyst's complex speciation behavior.
