142797-34-0

Basic information

• Product Name: SILYBIN (A and B)(P)
• Synonyms: SILYBIN (A and B)(P);NSC 227190;Silibinin B;(2R,3R)-3,5,7-Trihydroxy-2-[(2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin-6-yl]-4-chromanone;(2S,3S)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-[(2R,3R)-3,5,7-trihydroxy-4-oxobenzopyran-2-yl]benzodioxin
• CAS NO: 142797-34-0
• Molecular Formula: C₂₅H₂₂O₁₀
• Molecular Weight: 482.43618
• Mol File: 142797-34-0.mol

Chemical Properties

• Melting Point: 158-160℃ (methanol water )
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: SILYBIN (A and B)(P)(CAS DataBase Reference)
• NIST Chemistry Reference: SILYBIN (A and B)(P)(142797-34-0)
• EPA Substance Registry System: SILYBIN (A and B)(P)(142797-34-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 142797-34-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
SILYBIN (A and B)(P) is used as a therapeutic agent for its anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells. This makes it a promising candidate for the treatment of liver diseases, such as hepatitis and cirrhosis, where inflammation and fibrosis play significant roles in disease progression.
Additionally, due to its antioxidant and radical scavenging properties, SILYBIN (A and B)(P) can be used as a supplement in the nutraceutical industry to support liver health and promote overall well-being.
Used in Cosmetic Industry:
SILYBIN (A and B)(P) can be utilized as an active ingredient in cosmetic products, particularly those targeting skin health and regeneration. Its anti-inflammatory properties can help reduce skin irritation and promote healing, making it suitable for use in skincare products for various skin conditions, such as acne, eczema, and dermatitis.
Used in Research and Development:
SILYBIN (A and B)(P) serves as a valuable compound for scientific research, particularly in the fields of pharmacology, toxicology, and biochemistry. Its unique structure and biological activities make it an interesting subject for studying the mechanisms of action, potential drug interactions, and the development of novel therapeutic strategies for various diseases.

Upstream product

• 7572-90-9 ethyl 2-bromo-3-(4-benzyloxy-3-methoxyphenyl)-3-oxopropionate 
• 98314-87-5 (E)-3-[(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone 
• 98314-81-9 ethyl 2-<4-dimethoxymethyl-2-(methoxymethoxy)phenoxy>-3-(4-benzyloxy-3-methoxyphenyl)-3-oxopropionate 
• 98314-80-8 ethyl 2-<4-formyl-2-(methoxymethoxy)phenoxy>-3-(4-benzyloxy-3-methoxyphenyl)-3-oxopropionate 
• 98314-82-0 2-<4-dimethoxymethyl-2-(methoxymethoxy)phenoxy>-3-(4-benzyloxy-3-methoxyphenyl)-propane-1,3-diol 
• 98314-84-2 3-(4-benzyloxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-carbaldehyde 
• 98314-86-4 (2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde 
• 74741-36-9 (2R*,3R*)-3-(4-Hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-aldehyde 
• 65298-98-8 4-hydroxy-3-(methoxymethoxy)benzaldehyde 
• 98314-88-6 {3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone 
• 458-35-5 coniferol 
• 480-18-2 taxifolin 

Relevant articles and documents

Benzodioxans by Oxidative Phenol Coupling. Synthesis of Silybin

Oxidative coupling of substituted catechols with isoeugenol or coniferyl alcohol in the presence of silver oxide affords 2,3-trans-1,4-benzodioxans in good yield.The reaction is highly regioselective when the catechol bears an alkyl substituent, much less