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SILYBIN (A and B)(P) is a natural occurring flavolignan derived from the seeds of the milk thistle plant (Silybum marianum). It consists of two isomers, SILYBIN A and SILYBIN B, which possess various biological activities, including anti-inflammatory and anti-fibrogenic properties. The compound is characterized by its unique structure, which allows it to interact with various cellular targets and exhibit therapeutic effects.

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  • 142797-34-0 Structure
  • Basic information

    1. Product Name: SILYBIN (A and B)(P)
    2. Synonyms: SILYBIN (A and B)(P);NSC 227190;Silibinin B;(2R,3R)-3,5,7-Trihydroxy-2-[(2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin-6-yl]-4-chromanone;(2S,3S)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-[(2R,3R)-3,5,7-trihydroxy-4-oxobenzopyran-2-yl]benzodioxin
    3. CAS NO:142797-34-0
    4. Molecular Formula: C25H22O10
    5. Molecular Weight: 482.43618
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 142797-34-0.mol
  • Chemical Properties

    1. Melting Point: 158-160℃ (methanol water )
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: SILYBIN (A and B)(P)(CAS DataBase Reference)
    10. NIST Chemistry Reference: SILYBIN (A and B)(P)(142797-34-0)
    11. EPA Substance Registry System: SILYBIN (A and B)(P)(142797-34-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 142797-34-0(Hazardous Substances Data)

142797-34-0 Usage

Uses

Used in Pharmaceutical Industry:
SILYBIN (A and B)(P) is used as a therapeutic agent for its anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells. This makes it a promising candidate for the treatment of liver diseases, such as hepatitis and cirrhosis, where inflammation and fibrosis play significant roles in disease progression.
Additionally, due to its antioxidant and radical scavenging properties, SILYBIN (A and B)(P) can be used as a supplement in the nutraceutical industry to support liver health and promote overall well-being.
Used in Cosmetic Industry:
SILYBIN (A and B)(P) can be utilized as an active ingredient in cosmetic products, particularly those targeting skin health and regeneration. Its anti-inflammatory properties can help reduce skin irritation and promote healing, making it suitable for use in skincare products for various skin conditions, such as acne, eczema, and dermatitis.
Used in Research and Development:
SILYBIN (A and B)(P) serves as a valuable compound for scientific research, particularly in the fields of pharmacology, toxicology, and biochemistry. Its unique structure and biological activities make it an interesting subject for studying the mechanisms of action, potential drug interactions, and the development of novel therapeutic strategies for various diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 142797-34-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,7,9 and 7 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 142797-34:
(8*1)+(7*4)+(6*2)+(5*7)+(4*9)+(3*7)+(2*3)+(1*4)=150
150 % 10 = 0
So 142797-34-0 is a valid CAS Registry Number.

142797-34-0 Well-known Company Product Price

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  • Sigma-Aldrich

  • (59527)  Silybin B  analytical standard

  • 142797-34-0

  • 59527-5MG

  • 6,241.95CNY

  • Detail

142797-34-0Downstream Products

142797-34-0Relevant articles and documents

Benzodioxans by Oxidative Phenol Coupling. Synthesis of Silybin

Merlini, Lucio,Zanarotti, Antonio,Pelter, Andrew,Rochefort, Malcolm P.,Haensel, Rudolf

, p. 775 - 778 (2007/10/02)

Oxidative coupling of substituted catechols with isoeugenol or coniferyl alcohol in the presence of silver oxide affords 2,3-trans-1,4-benzodioxans in good yield.The reaction is highly regioselective when the catechol bears an alkyl substituent, much less

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