142917-39-3

Basic information

• Product Name: 2-(6-METHYL-1-BENZOFURAN-3-YL) ACETIC ACID
• Synonyms: 2-(6-METHYL-1-BENZOFURAN-3-YL) ACETIC ACID;(6-methyl-1-benzofuran-3-yl)acetic acid(SALTDATA: FREE)
• CAS NO: 142917-39-3
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.1953
• Mol File: 142917-39-3.mol

Chemical Properties

• Boiling Point: 344.8°Cat760mmHg
• Flash Point: 162.3°C
• Appearance: /
• Density: 1.267g/cm³
• Vapor Pressure: 2.44E-05mmHg at 25°C
• CAS DataBase Reference: 2-(6-METHYL-1-BENZOFURAN-3-YL) ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-METHYL-1-BENZOFURAN-3-YL) ACETIC ACID(142917-39-3)
• EPA Substance Registry System: 2-(6-METHYL-1-BENZOFURAN-3-YL) ACETIC ACID(142917-39-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 142917-39-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(6-METHYL-1-BENZOFURAN-3-YL) ACETIC ACID is used as an intermediate in the synthesis of various drugs and pharmaceutical compounds. Its unique chemical structure allows it to be a valuable building block for the development of new medications.
Used in Research:
2-(6-METHYL-1-BENZOFURAN-3-YL) ACETIC ACID is also used in research as a starting material for the synthesis of more complex organic molecules. Its specific chemical and biological properties make it a promising candidate for the development of novel compounds with potential applications in various fields.
Used in Organic Synthesis:
In the field of organic synthesis, 2-(6-METHYL-1-BENZOFURAN-3-YL) ACETIC ACID is used as a building block for the synthesis of more complex organic molecules. Its unique structure and functional groups make it a versatile component in the creation of new chemical entities with potential applications in various industries.

InChI:InChI=1/C11H10O3/c1-7-2-3-9-8(5-11(12)13)6-14-10(9)4-7/h2-4,6H,5H2,1H3,(H,12,13)/p-1

Upstream product

• 108-39-4 3-methyl-phenol 
• 41321-75-9 4-bromomethyl-7-methyl-coumarin 
• 20895-41-4 6-methylbenzofuran-3(2H)-one 
• 82156-60-3 (6-Methyl-benzofuran-3-yl)-acetic acid ethyl ester 

Downstream Products

• 1251950-13-6 C₂₀H₁₅N₅O₄S₂ 
• 1251950-12-5 N-({5-[(6-methyl-1-benzofuran-3-yl)methyl]-1,3,4-thiadiazol-2-yl}carbamothioyl)-4-hydroxybenzamide 
• 1251950-11-4 C₂₂H₂₀N₄O₃S₂ 
• 1251950-10-3 C₂₁H₁₈N₄O₃S₂ 
• 1251950-09-0 C₂₀H₁₅ClN₄O₂S₂ 
• 1251950-07-8 C₂₀H₁₅ClN₄O₂S₂ 
• 1251950-06-7 C₂₀H₁₅ClN₄O₂S₂ 
• 1251950-04-5 C₂₀H₁₆N₄O₂S₂ 
• 1264084-94-7 C₂₀H₂₂N₄O₄ 
• 1264084-89-0 C₁₈H₁₈N₄O₂ 
• 1264084-88-9 C₂₀H₁₈N₂O₄ 
• 1264084-87-8 C₁₈H₁₃ClN₂O₂ 
• 1264084-86-7 C₁₉H₁₆N₂O₂ 
• 1264084-85-6 1-(4-chlorophenyl)-3,5-dihydro-8-methyl-4H-[1]benzofuro[2,3-d][1,2]diazepine-4-one 

Relevant articles and documents

Synthesis and preliminary evaluation of benzofuran-oxadiazole conjugates as potential antitubercular agents

In the present study, a series of benzofuran-oxadiazole conjugates 7(a-o) was designed, synthesized and characterized through IR,1H NMR,13C NMR and mass spectral data. All the compounds were screened for preliminary antitubercular activity against Mycobacterium phlei and Mycobacterium tuberculosis H37RV. Among all the target compounds, the compound possessing chlorine (7k, MIC 1.56 μg/mL) and bromine (7m, MIC 1.56 μg/mL) on 6th position of benzofuran showed highest activity against Mycobacterium phlei. Whereas, bromine on either 5th position (7l, MIC 3.125 μg/mL) or 6th position (7m MIC 3.125 μg/mL) on benzofuran exhibited highest activity for Mycobacterium tuberculosis (H37 RV).

Synthesis, anti-microbial and anti-cancer evaluation study of 3-(3-benzofuranyl)-coumarin derivatives

The series of 3-coumarin-substituted benzofuran derivatives 4a-4j have been synthesized under optimized experimental condition with excellent yields. All the isolated compounds were characterized and screened anti-microbiological and anti-cancer activity. The anti-microbiological results observed were extremely good against S. aureus, C. albicans and A. Niger. The comparative docking studies with gyrase type IIA topoisomerase from mycobacterium tuberculosis docked with ligands and 4j have found lowest docked energy.

Efficient and Convenient Method for Synthesis of Benzofuran-3-acetic Acids and Naphthafuran-acetic Acids

Herein, we report an efficient and convenient method for synthesis of benzofuran-3-acetic acids and naphthafuran-acetic acids 5a-p by the reaction of substituted-4-bromomethylcoumarins with aqueous sodium hydroxide at refluxing temperature. The obtained products are characterized by infrared, 1H NMR, 13C NMR, and mass spectral data. Structures 5a and 5e are confirmed by their single x-ray diffraction studies. The advantages of this method are good yields, easy workup, and no chromatographic purifications.

A convenient synthesis of benzofuran-3-carboxyaldehydes

The benzofuran-3-acetic acids (3a-c) on treatment with pyridine N-oxide give benzofuran-3-carboxyaldehydes (5a-c) on reduction with NaBH4 in methanol yields naturally occurring benzofuran 6a which is converted into 6b and 6c by the literature method.