142917-39-3Relevant articles and documents
Synthesis and preliminary evaluation of benzofuran-oxadiazole conjugates as potential antitubercular agents
Negalurmath, Veerabhadrayya S.,Kotresh, Obelannavar,Basanagouda, Mahantesha
, p. 965 - 970 (2019/03/07)
In the present study, a series of benzofuran-oxadiazole conjugates 7(a-o) was designed, synthesized and characterized through IR,1H NMR,13C NMR and mass spectral data. All the compounds were screened for preliminary antitubercular activity against Mycobacterium phlei and Mycobacterium tuberculosis H37RV. Among all the target compounds, the compound possessing chlorine (7k, MIC 1.56 μg/mL) and bromine (7m, MIC 1.56 μg/mL) on 6th position of benzofuran showed highest activity against Mycobacterium phlei. Whereas, bromine on either 5th position (7l, MIC 3.125 μg/mL) or 6th position (7m MIC 3.125 μg/mL) on benzofuran exhibited highest activity for Mycobacterium tuberculosis (H37 RV).
Synthesis, anti-microbial and anti-cancer evaluation study of 3-(3-benzofuranyl)-coumarin derivatives
Chougala, Bahubali M.,Shastri, Samundeeswari L.,Holiyachi, Megharaja,Shastri, Lokesh A.,More, Sunil S.,Ramesh
, p. 4128 - 4138 (2015/11/02)
The series of 3-coumarin-substituted benzofuran derivatives 4a-4j have been synthesized under optimized experimental condition with excellent yields. All the isolated compounds were characterized and screened anti-microbiological and anti-cancer activity. The anti-microbiological results observed were extremely good against S. aureus, C. albicans and A. Niger. The comparative docking studies with gyrase type IIA topoisomerase from mycobacterium tuberculosis docked with ligands and 4j have found lowest docked energy.
Efficient and Convenient Method for Synthesis of Benzofuran-3-acetic Acids and Naphthafuran-acetic Acids
Basanagouda, Mahantesha,Narayanachar,Majati, Iranna B.,Mulimani, Shiddappa S.,Sunnal, Satish B.,Nadiger, Rohit V.,Ghanti, Ashok S.,Gudageri, Siddeshwar F.,Naik, Ravi,Nayak, Akshata
supporting information, p. 2195 - 2202 (2015/09/22)
Herein, we report an efficient and convenient method for synthesis of benzofuran-3-acetic acids and naphthafuran-acetic acids 5a-p by the reaction of substituted-4-bromomethylcoumarins with aqueous sodium hydroxide at refluxing temperature. The obtained products are characterized by infrared, 1H NMR, 13C NMR, and mass spectral data. Structures 5a and 5e are confirmed by their single x-ray diffraction studies. The advantages of this method are good yields, easy workup, and no chromatographic purifications.
A convenient synthesis of benzofuran-3-carboxyaldehydes
Deshpande, A. R.,Paradkar, M. V.
, p. 526 - 528 (2007/10/02)
The benzofuran-3-acetic acids (3a-c) on treatment with pyridine N-oxide give benzofuran-3-carboxyaldehydes (5a-c) on reduction with NaBH4 in methanol yields naturally occurring benzofuran 6a which is converted into 6b and 6c by the literature method.