20895-41-4

Basic information

• Product Name: 6-Methyl-3(2H)-benzofuranone
• Synonyms: 6-Methyl-3(2H)-benzofuranone;6-Methyl-1-Benzofuran-3-One;6-methylbenzofuran-3(2H)-one
• CAS NO: 20895-41-4
• Molecular Formula: C₉H₈O₂
• Molecular Weight: 148.15900
• Mol File: 20895-41-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 285oC at 760 mmHg
• Flash Point: 138.6oC
• Appearance: /
• Density: 1.211g/cm3
• Vapor Pressure: 0.00288mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 6-Methyl-3(2H)-benzofuranone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methyl-3(2H)-benzofuranone(20895-41-4)
• EPA Substance Registry System: 6-Methyl-3(2H)-benzofuranone(20895-41-4)

Safety Data

• Hazardous Substances Data: 20895-41-4(Hazardous Substances Data)

Usage

General Description

6-Methyl-3(2H)-benzofuranone, also known as maltol, is a natural organic compound with a sweet, caramel-like odor. It is commonly found in roasted malt, coffee, cocoa, and bread, as well as in some fruits and vegetables. Maltol is also used as a flavor enhancer in various food products and as a fragrance ingredient in perfumes and cosmetics. In addition to its use in the food and fragrance industries, maltol has been studied for its potential medicinal properties, including antioxidant, anti-inflammatory, and antimicrobial effects. Overall, 6-Methyl-3(2H)-benzofuranone is a versatile chemical compound with wide-ranging applications in various industries.

InChI:InChI=1/C9H8O2/c1-6-2-3-7-8(10)5-11-9(7)4-6/h2-4H,5H2,1H3

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• 60770-30-1 3-acetoxy-6-methyl-benzofuran 
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• 40926-72-5 2-(m-tolyloxy)acetyl chloride 

Downstream Products

• 142917-39-3 (6-methyl-1-benzofuran-3-yl)acetic acid 
• 143883-37-8 6-Methyl-benzofuran-3-carbaldehyde 
• 1618102-62-7 ethyl 2-(2-(2,4-dichlorophenyl)hydrazono)-2-(6-methyl-3-oxo-2,3-dihydrobenzofuran-2-yl)acetate 
• 1240996-28-4 ethyl ester of 1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carboxylic acid 
• 1240998-70-2 1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-0c]pyrazole-3-carboxylic acid 
• 1240996-80-8 N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide 
• 1240996-82-0 N-(pyrrolidin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide 
• 1240996-83-1 N-(morpholin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide 
• 1240996-86-4 N-cyclohexyl-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carboxamide 
• 1240997-06-1 N-adamant-2-yl-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carboxamide 
• 1240997-03-8 N-adamant-1-yl-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carboxamide 
• 1618102-57-0 N-menthyl-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carboxamide 
• 1618102-58-1 N-isopinocampheyl-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carboxamide 
• 1618102-59-2 N-bornyl-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carboxamide 

Relevant articles and documents

A Palladium-Catalyzed Oxa-(4+4)-Cycloaddition Strategy towards Oxazocine Scaffolds

A Pd-catalyzed oxa-(4+4)-cycloaddition between 1-azadienes and (2-hydroxymethyl)allyl carbonates is described. Aurone-derived azadienes furnished polycyclic 1,5-oxazocines in good yields. Interestingly, linear azadienes have also been involved and yielded monocyclic heterocycles with complete regioselectivity. DFT calculations were carried out to gain insight on this observation.

TRANSCRIPTION FACTOR BRN2 INHIBITORY COMPOUNDS AS THERAPEUTICS AND METHODS FOR THEIR USE

The invention provides a variety of compounds having the structure of Formula I and uses of such compounds for treatment of various indications, including cancer as well as methods of treatment involving such compounds are also provided. The uses of the compounds may specifically include: bladder cancer, cholangiocarcinoma; colorectal cancer; diffuse large B-cell lymphoma (DLBC); liver cancer; ovarian cancer; thymoma; thyroid cancer; clear cell renal cell carcinoma (CCRCC); chromophobe renal cell carcinoma (ChRCC); prostate cancer; breast cancer; uterine cancer; pancreatic cancer; cervical cancer; uveal melanoma; acute myeloid leukemia (AML); head and neck cancer; small cell lung cancer (SCLC); lung adenocarcinoma sarcoma; mesothelioma; adenoid cystic carcinoma (ACC), sarcoma; testicular germ cell cancer; uterine cancer; pheochromocytoma and paraganglioma (PCPG); melanoma; glioma; glioblastoma multiforme; T-cell Acute Lymphoblastic Leukemia; T-cell Lympohoma, medulloblastoma; and neuroblastoma.

Microwave-Assisted Synthesis of Benzofuran-3(2H)-ones

A new method for the synthesis of benzofuran-3(2H)-ones under microwave conditions was developed. The reaction conditions were screened, and the scope of benzoate substrates was investigated. The results showed that our method could provide rapid access to these important dihydrobenzofuranones in 43% to 58% yields.