- Substituted melatonin derivatives, process for their preparation, and methods of use
-
The invention provides 2 aryl substituted derivatives of melatonin. The invention further provides pharmaceutical compositions comprising such derivatives, methods for preparing such derivatives, and methods of using such derivatives to induce general ane
- -
-
Page/Page column 12
(2008/06/13)
-
- Synthesis and study of pigment aggregation response of some melatonin derivatives
-
This study was performed to investigate the reactivity of melatonin towards various chemical reagents to produce new derivatives of melatonin containing extra- or fused heterocyclic systems such as the imidazoindole derivatives 3, 5, 6, the triazinoindole
- Doss,Mohareb, Rafat M.,Elmegeed,Luoca
-
p. 607 - 613
(2007/10/03)
-
- Syntheses of melatonin and its derivatives
-
Two simple synthetic methods for melatonin are newly developed from tryptamine through intermediates, which are promising lead compounds for drug developing research. Novel chemical reactivities of melatonin in its bromination, lithiation, and acylation are also reported.
- Somei, Masanori,Fukui, Yoshikazu,Hasegawa, Masakazu,Oshikiri, Naoki,Hayashi, Toshikatsu
-
p. 1725 - 1736
(2007/10/03)
-
- Compounds effective in the treatment of circadian rhythms and related disorders, the novel pharmaceutical preparations and novel method of application
-
The novel compounds of formula: STR1 in which R is isopropyl, cyclohexyl, phenyl, CH 3, Br or I; or H R 1 is CH 3 or cyclopropyl and R 2 is H or Br, and when R 1 is cyclopropyl and R 2 is H, R is other than H, and when R 1 is CH 3 and R 2 is H, R is other than H, and when R 1 is CH 3 and R 2 is H, R is other than I, and when R is CH 3 and R 2 is H, R 1 is other than CH 3, and when R is phenyl and R 2 is H, R 1 is other than CH 3, exhibit superior activity in the treatment of pathologies which interfere with the circadian rhythm. A novel method of preparation is described according to which the pharmaceutical compositions containing the novel compounds, as well as compounds already known, are administered transdermally. The novel method of administration results in sustained peripheral blood level. Novel pharmaceutical compositions are described suitable for transdermal administration.
- -
-
-
- Pharmaceutical compositions active in the therapy of sleep disorders
-
The present invention relates to new pharmaceutical compositions active in the therapy of sleep disorders comprising N-acetyl-5-methoxy-triptamine (melatonin) or one of its derivatives, preferably 2-iodo-N-acetyl-5-methoxy-triptamine (2-iodomelatonin), 2-bromo-N-acetyl-5-methoxy-triptamine (2-bromomelatonin), 2-chloro-N-acetyl-5-methoxy-triptamine (2-chloromelatonin) or 6-chloro-N-acetyl-5-methoxy-triptamine (6-chloromelatonin), at a dosage comprised between 10 and 100 mg, preferably comprised respectively between 20 and 80 mg between 10 and 20 mg and between 10 and 40 mg alone or in association with a benzodiazepinic derivative at a dosage comprised between 0.06 and 25 mg.
- -
-
-
