142979-82-6Relevant articles and documents
5,5-Disubstituted Hydantoins: Syntheses and Anti-HIV Activity
Comber, Robert N.,Reynolds, Robert C.,Friedrich, Joyce D.,Manguikian, Roupen A.,Buckheit, Robert W.,et al.
, p. 3567 - 3572 (2007/10/02)
A series of 5,5-disubstituted hydantoin derivatives was synthesized by alkylating 5,5-bis(mercaptomethyl)-2,4-imidazolidinedione (3) with various halomethylaromatic or halomethylheteroaromatic precursors, or by using the Buchener-Berg procedure on the required ketone.When evaluated for their ability to inhibit HIV-induced cell killing and virus production in CEM or MT-2 cells only compounds 2, 4n, 4o, and 4i demonstrated modest activity, the latter with an IC50 = 53 μM