cas 14305-08-9, 4,5-DIBROMO-2-PHENYL-2,3-DIHYDROPYRIDAZIN-3-ONE | Articles data ｜lookchem

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14305-08-9

Articles about 14305-08-9Total 4 be found

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Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase
The synthesis, structure-activity relationship and modeling of a series of 5-substituted-N-aryl pyridazinone based p38α inhibitors are described. In comparing the series to the similar N-aryl pyridinone series, it was found that the pyridazinones maintain
Jerome, Kevin D.,Hepperle, Michael E.,Walker, John K.,Xing, Li,Devraj, Rajesh V.,Benson, Alan G.,Baldus, John E.,Selness, Shaun R.
scheme or table
p. 3146 - 3149
(2010/09/15)

Confirmation and prevention of halogen exchange: practical and highly efficient one-pot synthesis of dibromo- and dichloropyridazinones
Commercially available anilines were converted by a two step, one-pot process to the corresponding pyridazinones in good to excellent yields. During the process research, a significant halogen exchange was confirmed and prevented which allowed the process to be scaled to multikilogram quantities.
Zhang, Ji,Morton, Howard E.,Ji, Jianguo
p. 8733 - 8735
(2007/10/03)

Substituted pyridazinones
Disclosed are substituted pyridazinones that are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical composition containing the pyridazinone compounds, methods of preparing th
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Page 33

(2008/06/13)

Synthesis and pharmacological study of a series of 3(2H)-pyridazinones as analgesic and antiinflammatory agents
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Santagati,Duro,Caruso,Trombadore,Amico-Roxas
p. 921 - 929
(2007/10/02)

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Chemical Properties

Melting Point: 143ºC
Boiling Point: 340.1 °C at 760 mmHg
Flash Point:159.5 °C
Density: 1.89 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Vapor Pressure: 8.82E-05mmHg at 25°C
Refractive Index: 1.687
PSA: 34.89000
LogP: 2.75750

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