- CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF
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Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.
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Paragraph 1169
(2018/04/17)
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- Synthesis, reactions and theoretical studied of triazolotriazolopyrazinium-3-aminides
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Triazolopyrimidinium-3-aminides 5a-h have been synthesised by treatment pyridin-6-yl thiosemicarbazide derivatives 7f-n with dicyclohexylcarbodiimide (DCC).The above aminides 5a-h were slowly hydrolysed in water but very rapidly hydrolysed in 5 M aqueous hydrochloric acid to give substituted 1,2,4-triazole derivatives (e.g. 5a,d,g -> 8e,a,f, respectively); related nucleophilic ring-opening reactions occurred when the aminides (cf. 5a-h) were treated with (separately) methanol and ethanol (e.g. 5d->8c and 8d, respectively).A series of analogous triazolopyrazinium-3-aminides 6a-e was prepared following the procedures described above.The pyrazinium aminides 6 are stable in aq. 2 M HCl, and a stable hydrochloride salt 13 was formed from one such substrate 6a.
- Crabb, Derek L.,Main, David A.,Morley, John O.,Preston, Peter N.,Wright, Stanley H. B.
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- SYNTHESIS OF SUBSTITUTED METHYL ARYL KETONE PYRIMIDINYLOXIMES AND THEIR REACTIONS WITH NUCLEOPHILES
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Chloropyrimidines react readily with the sodium salts of alkyl aryl ketoximes to give acetophenone O-(2,4-dimethylpyrimidin-6-yl)- and O-(4,6-dimethylpyrimidin-2-yl)oximes, the oximino-groups in which readily undergo nucleophilic substitution.
- Danagulyan, G. G.,Balasanyan, N. G.,Terent'ev, P. B.,Zalinyan, M. G.
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p. 1369 - 1373
(2007/10/02)
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