14333-92-7

Basic information

• Product Name: 2-(4-ethylphenyl)-2-oxoacetaldehyde hydrate
• Synonyms: 2-(4-ethylphenyl)-2-oxoacetaldehyde hydrate
• CAS NO: 14333-92-7
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 0
• Mol File: 14333-92-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-ethylphenyl)-2-oxoacetaldehyde hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-ethylphenyl)-2-oxoacetaldehyde hydrate(14333-92-7)
• EPA Substance Registry System: 2-(4-ethylphenyl)-2-oxoacetaldehyde hydrate(14333-92-7)

Safety Data

• Hazardous Substances Data: 14333-92-7(Hazardous Substances Data)

Usage

Physical state

Pale yellow liquid

Odor

Fruity

Solubility

Soluble in organic solvents such as ethanol, ether, and acetone.

Uses

a. Production of various drugs
b. Building block in organic synthesis processes

Safety precautions

a. May cause skin and eye irritation
b. Handle with care

Storage conditions

Cool, dry, and well-ventilated area.

Upstream product

• 937-30-4 4-ethylacetophenone 
• 3454-07-7 1-ethenyl-4-ethyl-benzene 
• 40307-11-7 1-ethyl-4-ethynylbenzene 

Downstream Products

• 1350516-03-8 2-(4-ethylphenyl)quinoxaline 
• 128863-45-6 2-(4'-ethylphenyl)-3-methoxy-6-(2-methoxyphenoxy)imidazo<1,2-b>pyridazine 

Relevant articles and documents

Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4-Acyl-1,4-dihydropyridines

Herein we report the conversion of 4-Acyl-1,4-dihydropyridines (DHPs) into ynones under electrochemical conditions. The reaction proceeds via the homolysis of acyl-DHP under electron activation. The resulting acyl radicals react with hypervalent iodine(III) reagents to form the target ynones or ynamides in acceptable yields. This mild reaction condition allows wider functionality tolerance that includes halides, carboxylates, or alkenes. The synthetic utility of this methodology is further demonstrated by the late-stage modification of complex molecules.

Iodine-mediated oxidative annulation for one-pot synthesis of pyrazines and quinoxalines using a multipathway coupled domino strategy

An efficient iodine-mediated oxidative annulation of aryl acetylenes-arylethenes-aromatic ketones with 1,2-diamines for the synthesis of pyrazines and regioselective synthesis of quinoxalines is presented. A multipathway coupled domino approach has been developed for the one-pot synthesis of 1,4-diazines with high functional group compatibility.

3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS

A compound represented by the formula (1): wherein A is a nitrogen atom or CR4, B is an oxygen atom, a sulfur atom or NR9 (provided that when A is a nitrogen atom, B is not NH), R1 is a C2-14; aryl group, L1 is a bond, CR10R11, an oxygen atom, a sulfur atom or NR12, X is OR13, SR13 or NR14NR15, R2 is a hydrogen atom, a formyl group, a C1-10; alkyl group or the like, L2 is a bond or the like, L3 is a bond, CR17R18, an oxygen atom, a sulfur atom or NR19, L4 is a bond, CR20R21, an oxygen atom, a sulfur atom or NR22, Y is an oxygen atom, a sulfur atom or NR23, and R3 is a C2-14; aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.