Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group
Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.
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(2008/06/13)
Quinolone Antibacterials Containing the New 7- Side Chain: The Effects of the 1-Aminoethyl Moiety and Its Stereochemical Configurations on Potency and in Vivo Efficacy
A series of stereochemically pure 7--1,4-dihydro-4-oxoquinoline and 1,8-naphthyridine-3-carboxylic acids, with varied substituents at the 1-, 5-, and 8-positions, were synthesized to study the effects of the 7-3-(1-aminoe
Domagala, John M.,Hagen, Susan E.,Joannides, Themis,Kiely, John S.,Laborde, Edgardo,et al.
p. 871 - 882
(2007/10/02)
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