- CHIRALLY PURE ISOMERS OF ITRACONAZOLE AND INHIBITORS OF LANOSTEROL 14A- DEMETHYLASE FOR USE AS ANGIOGENESIS INHIBITORS
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Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject.
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- Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors
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Several analogues based on the lead structure of azalanstat were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). A number of these compounds, which are structurally distinct from metalloporphyrin HO inhibitors, were found to be selec
- Vlahakis, Jason Z.,Kinobe, Robert T.,Bowers, Raymond J.,Brien, James F.,Nakatsu, Kanji,Szarek, Walter A.
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p. 1457 - 1461
(2007/10/03)
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- Process for preparing 1,3-dioxolane derivatives
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This invention provides an improved process for the preparation of compounds of formula (I): STR1 wherein: n is 0, 1 or 2; each R1 is independently halo or lower alkyl; R2 is nitro or --N(R3)R4 where R3/su
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- 1,3-Dioxolane derivatives as cholesterol-lowering agents
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Compounds of formula (I): STR1 wherein n is 2 or 3; p is 0, 1 or 2; q is 0, 1 or 2; X is oxygen or S(O)t where t is 0, 1 or 2; each R1 is independently halo, lower alkyl, lower alkoxy, or trifluoromethyl; each R2 is indepe
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