14341-48-1

Basic information

• Product Name: BROMOACETIC ACID-D3
• Synonyms: BROMOACETIC-D2 ACID-D;BROMOACETIC ACID-D3;BROMOACETIC-D2 ACID-D, 98 ATOM % D
• CAS NO: 14341-48-1
• Molecular Formula: C₂H₃BrO₂
• Molecular Weight: 141.97
• Product Categories: Alphabetical Listings;BChemical Synthesis;Organic Acids;Stable Isotopes;Synthetic Reagents
• Mol File: 14341-48-1.mol

Chemical Properties

• Melting Point: 47-49 °C(lit.)
• Boiling Point: 208 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 2.046g/cm³
• Vapor Pressure: 0.0929mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: BROMOACETIC ACID-D3(CAS DataBase Reference)
• NIST Chemistry Reference: BROMOACETIC ACID-D3(14341-48-1)
• EPA Substance Registry System: BROMOACETIC ACID-D3(14341-48-1)

Safety Data

• Hazard Codes: T,C,N
• Statements: 23/24/25-35-50-43
• Safety Statements: 26-36/37/39-45-61
• RIDADR: UN 3425 8/PG 2
• WGK Germany: 2
• Hazardous Substances Data: 14341-48-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
BROMOACETIC ACID-D3 is used as a building block for the synthesis of various pharmaceutical compounds. Its deuterated nature provides unique properties that can enhance the stability, solubility, and bioavailability of the resulting drugs.
Used in Allergy Treatment:
BROMOACETIC ACID-D3 is used as a CRTH2 antagonist for the treatment of allergic diseases, eosinophil-related diseases, and basophil-related diseases. As a CRTH2 antagonist, it helps in modulating the immune response and reducing inflammation associated with these conditions.
Used in Chemical Research:
BROMOACETIC ACID-D3 is used as a stable isotope-labeled compound in chemical research and analysis. The presence of deuterium allows for easier detection and tracking of the compound in various experimental setups, making it a valuable tool for studying chemical reactions and mechanisms.
Used in Environmental Studies:
BROMOACETIC ACID-D3 can be employed in environmental studies to understand the behavior and fate of bromoacetic acid in the environment. The deuterated compound can serve as a tracer, providing insights into the transport, degradation, and bioaccumulation of bromoacetic acid in ecosystems.
Used in Analytical Chemistry:
BROMOACETIC ACID-D3 is used as an internal standard in analytical chemistry, particularly in mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. The deuterated compound provides a stable reference for accurate quantification and identification of other compounds in a sample.

InChI:InChI=1/C2H3BrO2/c3-1-2(4)5/h1H2,(H,4,5)/i1D2/hD

Upstream product

• 1186-52-3 tetradeuterioacetic acid 
• 813-56-9 tetradeuterio-malonic acid 
• 343929-83-9 C₃⁽²⁾H₃BrO₄ 

Downstream Products

• 14341-47-0 ethyl bromo-<2,2-²H2>acetate 
• 19215-15-7 phenoxyacetic-d2 acid 
• 1239453-24-7 C₁₂H₁₁⁽²⁾H₂BrO₄ 

Relevant articles and documents

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Catalytic Enantioselective [2,3]-Rearrangements of Allylic Ammonium Ylides: A Mechanistic and Computational Study

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New insights into poly(lactic- co -glycolic acid) microstructure: Using repeating sequence copolymers to decipher complex NMR and thermal behavior

Sequence, which Nature uses to spectacular advantage, has not been fully exploited in synthetic copolymers. To investigate the effect of sequence and stereosequence on the physical properties of copolymers, a family of complex isotactic, syndiotactic, and atactic repeating sequence poly(lactic-co-glycolic acid) copolymers (RSC PLGAs) were prepared and their NMR and thermal behavior was studied. The unique suitability of polymers prepared from the bioassimilable lactic and glycolic acid monomers for biomedical applications makes them ideal candidates for this type of sequence engineering. Polymers with repeating units of LG, GLG and LLG (L = lactic, G = glycolic) with controlled and varied tacticities were synthesized by assembly of sequence-specific, stereopure dimeric, trimeric, and hexameric segmer units. Specifically labeled deuterated lactic and glycolic acid segmers were likewise prepared and polymerized. Molecular weights for the copolymers were in the range Mn = 12-40 kDa by size exclusion chromatography in THF. Although the effects of sequence-influenced solution conformation were visible in all resonances of the 1H and 13C NMR spectra, the diastereotopic methylene resonances in the 1H NMR (CDCl3) for the glycolic units of the copolymers proved most sensitive. An octad level of resolution, which corresponds to an astounding 31-atom distance between the most separated stereocenters, was observed in some mixed sequence polymers. Importantly, the level of sensitivity of a particular NMR resonance to small differences in sequence was found to depend on the sequence itself. Thermal properties were also correlated with sequence.

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