1186-52-3 Usage
Chemical Properties
colourless liquid
Uses
Different sources of media describe the Uses of 1186-52-3 differently. You can refer to the following data:
1. (Acetic acid-D4) Labelled Acetic Acid is used for analysis and profiling of biological samples resolved through NMR spectroscopy. It helps with the labelling of RNA for high resolution NMR.
2. Acetic acid-d{4} is used as a deuterated, polar and protic solvent, in food preservatives, PH control agent, flavor enhancer.
3. Acetic acid-d4 may be used in the synthesis of deuterated (7E,9Z)-CLA (conjugated linoleic acid) and Pr(CD3COO)3.D2O (deuterium analog of praseodymium (III) acetate hydrate).
General Description
Acetic acid-d4 (deuterated acetic acid) is a deuterated NMR solvent containing 0.03% (v/v) TMS (tetramethylsilane). It is useful in NMR-based research and analyses. Its dissociation constant in deuterium oxide has been obtained over a range of temperature by emf method.
Check Digit Verification of cas no
The CAS Registry Mumber 1186-52-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,8 and 6 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1186-52:
(6*1)+(5*1)+(4*8)+(3*6)+(2*5)+(1*2)=73
73 % 10 = 3
So 1186-52-3 is a valid CAS Registry Number.
InChI:InChI=1/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/i1D3/hD
1186-52-3Relevant articles and documents
Potter,Ritter
, p. 1040 (1954)
1,1-Ethenediol: The Long Elusive Enol of Acetic Acid
Eckhardt, André K.,Mardyukov, Artur,Schreiner, Peter R.
, (2020)
We present the first spectroscopic identification of hitherto unknown 1,1-ethenediol, the enol tautomer of acetic acid. The title compound was generated in the gas phase through flash vacuum pyrolysis of malonic acid at 400 °C. The pyrolysis products were
Ortho-Deuteration of Aromatic Aldehydes via a Transient Directing Group-Enabled Pd-Catalyzed Hydrogen Isotope Exchange
Kong, Junhua,Jiang, Zhi-Jiang,Xu, Jiayuan,Li, Yan,Cao, Hong,Ding, Yanan,Tang, Bencan,Chen, Jia,Gao, Zhanghua
, p. 13350 - 13359 (2021/10/01)
A practical and scalable ortho-selective deuteration of aromatic aldehydes was accomplished by Pd-catalyzed hydrogen isotope exchange with deuterium oxide as an inexpensive deuterium source. The use of tert-leucine as a transient directing group facilitates the exchange, affording a wide range of ortho-deuterated aromatic aldehydes with deuterium incorporation up to 97%. The control experiments suggest that the addition of silver trifluoroacetate resists the unexpected reduction of Pd(II), while the theoretical study indicates a rapid reversible concerted metalation-deprotonation process.
