143426-49-7

Basic information

• Product Name: (4-Pyrazol-1-ylphenyl)methanol
• Synonyms: (4-PYRAZOL-1-YL-PHENYL)METHANOL;4-(1-PYRAZOLYL)BENZYLALCOHOL;[4-(1H-PYRAZOL-1-YL)PHENYL]METHANOL;BUTTPARK 98\50-44;RARECHEM AL BD 1319;4-Pyrazol-1-ylbenzyl alcohol;(4-PYRAZOL-1-YL-PHENYL)METHANOL 95%;4-(1H-Pyrazol-1-yl)benzyl alcohol
• CAS NO: 143426-49-7
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.2
• Product Categories: Alcohols and Derivatives;Heterocycles;Pyrazole series
• Mol File: 143426-49-7.mol

Chemical Properties

• Melting Point: 76-80°C
• Boiling Point: 324.259 °C at 760 mmHg
• Flash Point: 149.907 °C
• Appearance: /
• Density: 1.167 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.25±0.10(Predicted)
• CAS DataBase Reference: (4-Pyrazol-1-ylphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Pyrazol-1-ylphenyl)methanol(143426-49-7)
• EPA Substance Registry System: (4-Pyrazol-1-ylphenyl)methanol(143426-49-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 143426-49-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(4-Pyrazol-1-ylphenyl)methanol is used as a building block for the synthesis of pharmaceutical compounds due to its unique chemical structure and reactivity, contributing to the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
(4-Pyrazol-1-ylphenyl)methanol is used as a reagent in organic synthesis for the formation of carbon-carbon and carbon-nitrogen bonds, facilitating the creation of complex organic molecules and contributing to advancements in chemical research and development.
Used in Medicinal Chemistry:
(4-Pyrazol-1-ylphenyl)methanol is utilized in medicinal chemistry for its potential applications in the discovery and design of new pharmaceutical agents, leveraging its pyrazole derivative properties to enhance drug efficacy and target specificity.
Used in Agrochemicals:
(4-Pyrazol-1-ylphenyl)methanol is employed in the agrochemical industry for its potential use in the development of new pesticides, herbicides, and other agricultural chemicals, improving crop protection and yield through innovative chemical solutions.

InChI:InChI=1/C10H10N2O/c13-8-9-2-4-10(5-3-9)12-7-1-6-11-12/h1-7,13H,8H2

Upstream product

• 400750-29-0 methyl 4-(1H-pyrazol-1-yI)benzenecarboxylate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 1122-91-4 4-bromo-benzaldehyde 
• 99662-34-7 4-(1H-pyrazol-1-yl)benzaldehyde 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 143426-47-5 4-pyrazol-1-yl-benzoic acid ethyl ester 
• 619-44-3 methyl 4-iodobenzoate 

Downstream Products

• 1174064-63-1 4-(4-bromo-1H-pyrazol-1-yl)benzaldehyde 
• 1187451-41-7 (6-((4-(pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid 
• 1187451-19-9 isopropyl 2-{[6-({N-[4-(1H-pyrazol-1-yl)benzyl]pyridine-3-sulfonamido}methyl)pyridin-2-yl]amino}acetate 

Relevant articles and documents

HETEROAROMATIC COMPOUNDS AND USES THEREOF

Providing heteraromatic compounds and uses thereof. In particular, providing heteraromatic compounds of formula (I), pharmaceutical compositions comprising same, methods for preparing same and uses thereof, wherein the variables are as defined in the description.

Combined KOH/BEt3Catalyst for Selective Deaminative Hydroboration of Aromatic Carboxamides for Construction of Luminophores

The selective catalytic C-N bond cleavage of amides into value-added amine products is a desirable but challenging transformation. Molecules containing iminodibenzyl motifs are prevalent in pharmaceutical molecules and functional materials. Here we established a combined KOH/BEt3 catalyst for deaminative hydroboration of acyl-iminodibenzyl derivatives, including nonheterocyclic carboxamides, to the corresponding amines. This novel transition-metal-free methodology was also applied to the construction of Clomipramine and luminophores.

PYRROLIDINE GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, W, R3b, Z and p have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

SUBSTITUTED AZACYCLES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers or pharmaceutically acceptable salt (s) thereof as muscarinic M1 receptor positive allosteric modulators (M1 PAMs). The present invention describe

MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers or pharmaceutically acceptable salt (s) thereof as muscarinic M1 receptor positive allosteric modulators (M1 PAMs). The present invention describes the preparation, pharmaceutical composition and the use of compound formula (I).

ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE

The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. (I) wherein each symbol is as described in the specification, or a salt thereof.

Aromatic hydrazides as specific inhibitors of bovine serum amine oxidase

New hydrazides were synthesized in search for specific inhibitors of bovine serum amine oxidase: a series of benzoic and phenylacetic acid hydrazides containing the 1H-imidazol-1-yl or the 1H-imidazol-1-ylmethyl group as (o,m,p)-substituent in the phenyl ring; an analogous series of p-substituted phenylhydrazides with 5 or 6-membered heterocyclic ring as substituent, and a series of similar phenylpropionic hydrazides. The longer and more flexible phenylacetic hydrazides, and to a somewhat lesser extent the phenylpropionic ones, were better specific inhibitors of bovine serum amine oxidase than the benzoic hydrazides, which were also bound by the enzyme with high affinity, but at a slow rate. Derivatives with p- and m-substituents were more reactive than the o-substituted ones. The chemical nature of the substituent was less important than its position in the phenyl ring and the presence of methylene spacers. These data point to the presence of a hydrophobic site at short distance from the protein carbonyl cofactor, so that simultaneous interaction of the 2 ends of the inhibitor molecule can occur at the 2 sites. The presence of the hydrophobic site was confirmed by the capability of some molecule deprived of the hydrazidic group to act as mild inhibitors. All hydrazides were less reactive by 2-3 orders of magnitude towards pig kidney diamine oxidase and FAD-dependent monoamine oxidase from rat brain mitochondria, while the other compounds showed similar inhibition power against all proteins. The specificity for the bovine enzyme seems therefore to be related to the concerted action of the 2 moieties of the inhibitor molecule.