Rational approaches to the design of cationic gemini surfactants for gene delivery
We report a new class of amphiphilic gemini surfactants as vehicles for gene delivery into cells, and the beginnings of a systematic structure-activity study. Preliminary results suggest that combining gemini surfactants with dioleoylphosphatidylethanolamine (DOPE) should allow the preparation of liposomes of various sizes and lipid compositions. Control of such colloidal changes could be as significant as the changes in the molecular composition of the gemini surfactants in delivering optimum gene expression in animal models.
A convenient synthesis of chiral sulfur-containing macrocyclic ligands
Eight new chiral sulfur-containing macrocyclic ligands, which can he used in chiral recognition and modificated furtherly for various uses, have been synthesized and characterized.
Synthesis of C2-symmetrical bis-β-amino alcohols from (R)-cysteine and their application in enantioselective catalysis
Six new sulfur-containing C2-symmetrical bis-β-primary and sec-amino- tert-alcohols have been synthesized from (R)-cysteine and applied successfully in the enantiocontrolled catalytic addition of diethylzinc to benzaldehyde. The resulting 1-phe
Kossenjans, Michael,Martens, Juergen
p. 1409 - 1417
(2007/10/03)
Chiral (Macrocyclic) Sulfide- and Sulfide/Alkylamino-Containing Ligands for Nickel-Catalyzed Grignard Cross-Coupling Reactions
Some macrocycles that contain sulfide and/or amino linkages as coordination sites have been examined as ligands for the nickel-catalyzed cross-coupling of the Grignard reagent of 1-phenyl-1-chloroethane with vinyl vromide to provide (1-methyl-2-propenyl)b
Vriesema, Bindert K.,Lemaire, Marc,Buter, Jan,Kellogg, Richard M.
p. 5169 - 5177
(2007/10/02)
MACROCYCLES WITH SULFIDE AND AMINE BINDING SITES AS CHIRAL LIGANDS FOR NICKEL CATALYZED CROSS COUPLING OF A GRIGNARD REAGENT WITH VINYL BROMIDE
Syntethic routes to macrocycles derived from (S)-phenyl alanine and (S)-cysteine have been developed.The catalyzed coupling of the Grignard reagent of 1-chloro-1-phenylethane and vinyl bromide in the presence of these ligands proceeds usually in good yields and in enantiomeric excesse (e.e.) of up to 46percent.
Lemaire, Marc,Vrisema, Bindert K.,Kellogg, Richard M.
p. 3499 - 3502
(2007/10/02)
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