14344-49-1Relevant articles and documents
Rational approaches to the design of cationic gemini surfactants for gene delivery
McGregor,Perrin,Monck,Camilleri,Kirby
, p. 6215 - 6220 (2001)
We report a new class of amphiphilic gemini surfactants as vehicles for gene delivery into cells, and the beginnings of a systematic structure-activity study. Preliminary results suggest that combining gemini surfactants with dioleoylphosphatidylethanolamine (DOPE) should allow the preparation of liposomes of various sizes and lipid compositions. Control of such colloidal changes could be as significant as the changes in the molecular composition of the gemini surfactants in delivering optimum gene expression in animal models.
Synthesis of C2-symmetrical bis-β-amino alcohols from (R)-cysteine and their application in enantioselective catalysis
Kossenjans, Michael,Martens, Juergen
, p. 1409 - 1417 (2007/10/03)
Six new sulfur-containing C2-symmetrical bis-β-primary and sec-amino- tert-alcohols have been synthesized from (R)-cysteine and applied successfully in the enantiocontrolled catalytic addition of diethylzinc to benzaldehyde. The resulting 1-phe
MACROCYCLES WITH SULFIDE AND AMINE BINDING SITES AS CHIRAL LIGANDS FOR NICKEL CATALYZED CROSS COUPLING OF A GRIGNARD REAGENT WITH VINYL BROMIDE
Lemaire, Marc,Vrisema, Bindert K.,Kellogg, Richard M.
, p. 3499 - 3502 (2007/10/02)
Syntethic routes to macrocycles derived from (S)-phenyl alanine and (S)-cysteine have been developed.The catalyzed coupling of the Grignard reagent of 1-chloro-1-phenylethane and vinyl bromide in the presence of these ligands proceeds usually in good yields and in enantiomeric excesse (e.e.) of up to 46percent.