- INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE
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Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1 -mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
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Paragraph 0436-0437
(2021/03/13)
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- INHIBITORS OF CGAS FOR TREATING AUTOINFLAMMATORY DISEASES AND CANCER METASTASIS
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Tri-cyclyl nitrogen-containing heterocyclic compounds are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.
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Paragraph 0216
(2020/09/30)
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- Preparation method of 3,5-dichloro-4-fluorobromobenzene compound
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The invention relates to a preparation method of 3,5-dichloro-4-fluorobromobenzene. According to the preparation method, 2-fluoro-3-chloronitrobenzene is used as a starting raw material and subjectedto bromination, reduction and diazochlorination to synthesize 3,5-dichloro-4-fluorobromobenzene. The whole synthesis route of the method has the advantages of accessible raw materials, mild reaction conditions, environment friendliness, low equipment requirements and high product purity and yield.
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Paragraph 0036-0040
(2020/12/14)
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- Indole compound as well as preparation method, pharmaceutical composition and application thereof
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The invention discloses an indole compound as well as a preparation method, a pharmaceutical composition and an application thereof. Specifically, the invention relates to an indole derivative as shown in a general formula I and a medicinal salt thereof, a preparation method of the indole derivative, a composition containing one or more compounds, and applications of the compounds in preparation of medicines for preventing and/or treating diseases related to IDO1 and/or TDO.
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Paragraph 0681-0686
(2019/12/02)
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- 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4, 3-B]INDOLE INHIBITORS OF CGAS FOR TREATING AUTOINFLAMMATORY DISEASES
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1-(3,4-Dihydro-1H-pyrido[4, 3-b]indol-2(5H)-yl)-2-hydroxyethanones are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.
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Paragraph 0108
(2019/08/26)
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- BENZIMIDAZOLES FOR USE IN THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES
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Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a condition, disorder, or disease mediated by a lipid kinase or a protein kinase with benzimidazoles, for example, of Formula I or II, and pharmaceutical compositions thereof. Also provided herein are benzimidazoles, and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.
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Paragraph 00494
(2017/04/11)
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