cas 14370-74-2, 3-HYDROXY-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER | Articles data ｜lookchem

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14370-74-2

Articles about 14370-74-2Total 6 be found

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ARYL AND HETEROARYL-CARBOXAMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS TYK2 INHIBITORS
Novel carboxamide substituted compounds of Formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Tyrosine Kinase 2 (Tyk2).
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(2021/10/15)

Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists
A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPARγ modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.
Dropinski, James F.,Akiyama, Taro,Einstein, Monica,Habulihaz, Bahanu,Doebber, Tom,Berger, Joel P.,Meinke, Peter T.,Shi, Guo Q.
p. 5035 - 5038
(2007/10/03)

3-substituted indole antiproliferative angiogenesis inhibitors
3-Substituted indole carbohydrazides having the formula are useful for inhibiting angiogenesis and cell proliferation. Also disclosed are compositions which inhibit angiogenesis and cell proliferation and methods of inhibiting angiogenesis and cancer in a mammal.
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(2008/06/13)

A concise synthesis of 3-hydroxyindole-2-carboxylates by a modified Baeyer-Villiger oxidation
Indole-2-carboxylates are converted in good yields to 3-hydroxyindole-2-carboxylates by use of a Vilsmeier-Haack/Baeyer-Villiger reaction sequence. A systematic examination of the various indole substituents revealed this route to be general in scope. (C) 2000 Published by Elsevier Science Ltd.
Hickman,Sturino,Lachance
p. 8217 - 8220
(2007/10/03)

Regiospecific functionalization of indole-2-carboxylates and diastereoselective preparation of the corresponding indolines
The N-acyl derivatives of 3-substituted indole-2-carboxylates prepared through several routes were submitted to catalytic hydrogenation affording either cis- or trans-indoline diastereomers after quantitative C-2 epimerization.
Collot, Valerie,Schmitt, Martine,Marwah, Padma,Bourguignon, Jean-Jacques
p. 2823 - 2847
(2007/10/03)

Removal of Toluene-p-sulphonyl Groups from Sulphonamides. Part 5. Reactions of Phenylglyoxal Imines and some Tosylimines
Phenylglyoxal anil monomers have been shown to react with several nucleophilic reagents and the structures of the products have been elucidated.Various N-tosylarylimines also react with nucleophiles to give useful products.Phenacylimidates underwent cycloadditions with diphenylketen; such reactions gave complex results with phenacylimines, but the latter reacted with conjugated dienes in the presence of BF3 to give cycloaddition products in good yield.
McKay, William R.,Proctor, George R.
p. 2443 - 2450
(2007/10/02)

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Chemical Properties

Boiling Point: 369.492°C at 760 mmHg
Flash Point:177.263°C
Density: 1.326
Storage Temp.:2-8°C
Vapor Pressure: 0mmHg at 25°C
PSA: 62.32000
LogP: 2.05020

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