14370-74-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Hydroxy-1H-indole-2-carboxylic acid ethyl ester is used as an intermediate in the synthesis of various pharmaceutical compounds for its potential applications in drug development.
Used in Antimicrobial Applications:
In the field of antimicrobial research, 3-Hydroxy-1H-indole-2-carboxylic acid ethyl ester is used as an antimicrobial agent, exhibiting properties that can help combat various types of bacteria.
Used in Antiviral Applications:
3-Hydroxy-1H-indole-2-carboxylic acid ethyl ester is utilized as an antiviral agent, showing potential in inhibiting the replication and spread of viruses.
Used in Anti-inflammatory Applications:
In the area of anti-inflammatory research, 3-Hydroxy-1H-indole-2-carboxylic acid ethyl ester is employed as an agent to reduce inflammation, potentially providing relief for various inflammatory conditions.
Used in Medicinal Chemistry Studies:
3-Hydroxy-1H-indole-2-carboxylic acid ethyl ester is used as a lead compound in medicinal chemistry studies, where it is further investigated and modified to enhance its therapeutic potential and optimize its properties for specific medical applications.

InChI:InChI=1/C11H11NO3/c1-2-15-11(14)9-10(13)7-5-3-4-6-8(7)12-9/h3-6,12-13H,2H2,1H3

Upstream product

• 6414-58-0 diethyl 2-phenylaminomalonate 
• 28048-30-8 3-oxo-1-oxy-3H-indole-2-carboxylic acid ethyl ester 
• 56424-75-0 ethyl 2-[(2-ethoxy-2-oxo-ethyl)amino]benzoate 
• 91137-49-4 Indolon-carbonsaeure-2-ethylester 
• 194278-12-1 ethyl N-(2-methoxycarbonylphenyl)glycine ester 
• 18450-27-6 ethyl 3-formyl-1H-indole-2-carboxylate 
• 13622-59-8 N-(2-methoxycarbonylphenyl)glycine methyl ester 
• 141-52-6 sodium ethanolate 
• 3770-50-1 2-carbethoxyindole 
• 62-53-3 aniline 
• 87-25-2 2-ethoxycarbonylaniline 
• 612-42-0 phenylglycine-o-carboxylic acid 
• 14370-73-1 methyl N-ethoxycarbonylmethyl-N-tosylanthranilate 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 23740-95-6 2-methyl-2-(2-methyl-1H-indol-3-yl)-1,2-dihydro-3H-indol-3-one 
• 23740-96-7 2,2'-dimethyl-[2,2'-biindoline]-3,3'-dione 
• 89-52-1 o-acetylamino-benzoic acid 
• 58074-24-1 3-Hydroxy-4,5,6,7-tetrahydro-2-indolcarbonsaeure-ethylester 
• 911818-14-9 3-(3-trifluoromethyl-phenoxy)-1-(4-trifluoromethyl-phenyl)-1H-indole-2-carboxylic acid ethyl ester 
• 911816-10-9 1-(4-tert-butyl-phenyl)-3-(4-trifluoromethoxy-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 
• 911815-92-4 1-(4-tert-butyl-phenyl)-3-(3-trifluoromethyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 
• 911818-21-8 1-(3-isopropyl-phenyl)-3-(4-trifluoromethyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 
• 911818-09-2 1-(4-methoxy-phenyl)-3-(3-trifluoromethyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 
• 911818-15-0 1-(3-isopropyl-phenyl)-3-(3-trifluoromethyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 
• 911816-77-8 1-(4-tert-butyl-phenyl)-3-(3-ethoxy-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 
• 911817-00-0 1-(4-tert-butyl-phenyl)-3-(3-hydroxy-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 
• 911818-22-9 3-(3-hydroxy-phenoxy)-1-(3-isopropyl-phenyl)-1H-indole-2-carboxylic acid ethyl ester 
• 911815-52-6 3-hydroxy-1-(4-trifluoromethyl-phenyl)-1H-indole-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

ARYL AND HETEROARYL-CARBOXAMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS TYK2 INHIBITORS

Novel carboxamide substituted compounds of Formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Tyrosine Kinase 2 (Tyk2).

Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists

A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPARγ modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.

3-substituted indole antiproliferative angiogenesis inhibitors

3-Substituted indole carbohydrazides having the formula are useful for inhibiting angiogenesis and cell proliferation. Also disclosed are compositions which inhibit angiogenesis and cell proliferation and methods of inhibiting angiogenesis and cancer in a mammal.

A concise synthesis of 3-hydroxyindole-2-carboxylates by a modified Baeyer-Villiger oxidation

Indole-2-carboxylates are converted in good yields to 3-hydroxyindole-2-carboxylates by use of a Vilsmeier-Haack/Baeyer-Villiger reaction sequence. A systematic examination of the various indole substituents revealed this route to be general in scope. (C) 2000 Published by Elsevier Science Ltd.

Regiospecific functionalization of indole-2-carboxylates and diastereoselective preparation of the corresponding indolines

The N-acyl derivatives of 3-substituted indole-2-carboxylates prepared through several routes were submitted to catalytic hydrogenation affording either cis- or trans-indoline diastereomers after quantitative C-2 epimerization.

Removal of Toluene-p-sulphonyl Groups from Sulphonamides. Part 5. Reactions of Phenylglyoxal Imines and some Tosylimines

Phenylglyoxal anil monomers have been shown to react with several nucleophilic reagents and the structures of the products have been elucidated.Various N-tosylarylimines also react with nucleophiles to give useful products.Phenacylimidates underwent cycloadditions with diphenylketen; such reactions gave complex results with phenacylimines, but the latter reacted with conjugated dienes in the presence of BF3 to give cycloaddition products in good yield.