143722-25-2

Basic information

• Product Name: [2-[2-(TRIPHENYLMETHYL)-2H-TETRAZOL-5-YL]PHENYL]BORONIC ACID
• Synonyms: [2-[2-(TRIPHENYLMETHYL)-2H-TETRAZOL-5-YL]PHENYL]BORONIC ACID;2-(2-TRITYL-2H-TETRAZOL-5-YL)PHENYLBORONIC ACID;2-[2-(triphenylmethyl)-2H-trtrazol-5-yl]phenylboronicacid;2-(1-Trityl-1H-tetrazol-5-yl)phenylboronic acid;B-[2-[2-(TriphenylMethyl)-2H-tetrazol-5-yl]phenyl]boronic Acid;(1-Trityl-1H-tetrazol-5-yl)phenylboronic acid;Boronic acid,B-[2-[2-(triphenylmethyl)-2H-tetrazol-5-yl]phenyl]-
• CAS NO: 143722-25-2
• Molecular Formula: C₂₆H₂₁BN₄O₂
• Molecular Weight: 432.28154
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 143722-25-2.mol

Chemical Properties

• Boiling Point: 685.156 °C at 760 mmHg
• Flash Point: 368.169 °C
• Appearance: /
• Density: 1.20
• Vapor Pressure: 1.03E-19mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: Refrigerator
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 7.97±0.58(Predicted)
• CAS DataBase Reference: [2-[2-(TRIPHENYLMETHYL)-2H-TETRAZOL-5-YL]PHENYL]BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: [2-[2-(TRIPHENYLMETHYL)-2H-TETRAZOL-5-YL]PHENYL]BORONIC ACID(143722-25-2)
• EPA Substance Registry System: [2-[2-(TRIPHENYLMETHYL)-2H-TETRAZOL-5-YL]PHENYL]BORONIC ACID(143722-25-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 143722-25-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

An intermediate in the synthesis of Losartan

InChI:InChI=1/C26H21BN4O2/c32-27(33)24-19-11-10-18-23(24)25-28-29-30-31(25)26(20-12-4-1-5-13-20,21-14-6-2-7-15-21)22-16-8-3-9-17-22/h1-19,32-33H

Upstream product

• 18039-42-4 5-Phenyl-1H-tetrazole 
• 5419-55-6 Triisopropyl borate 
• 76-83-5 trityl chloride 
• 87268-78-8 2-trityl-5-phenyl-2H-tetrazole 

Downstream Products

• 133909-99-6 2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol 
• 177846-25-2 Methyl 1-butyl-5-ethyl-3-[[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-1H-pyrazole-4-carboxylate 
• 177846-24-1 1-Butyl-3-ethyl-5-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-pyrazole-4-carboxylic acid methyl ester 

Relevant articles and documents

PREPARATION AND UTILITY OF SUBSTITUTED PHENYLTETRAZOLES

Disclosed herein are substituted phenyltetrazoles of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and the methods of their use thereof.

INSULIN SENSITIVITY WITH ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES

This invention relates to a novel method of using an Angiotensin II antagonist for the improvement of insulin sensitivity alone or in conjunction with the treatment of hypertension. Angiotensin II antagonists such as the class of substituted imidazoles represented by formula I: STR1 and specifically by Losartan, 2-butyl-4-chloro-1-[(2'-tetrazol-5-yl)biphenyl-4-yl]methyl]-5-(hydroxymethyl)imidazole potassium salt.

PROCESS FOR PREPARING BIPHENYLTETRAZOLE COMPOUNDS

Method for the preparing biphenyltetrazole compounds which are angiotensin II receptor antagonists or which are useful intermediates to prepare angiotensin II receptor antagonists. An illustrative biphenyl tetrazole compound is 2-n-butyl-4-chloro-1-[(2'-(tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imi dazole-5-methanol, potassium salt.

PRODRUGS OF IMIDAZOLE CARBOXYLIC ACIDS AS ANGIOTENSIN II RECEPTOR ANTAGONISTS

Prodrugs of imidazole carboxylic acids which are AII antagonists useful in treating hypertension, pharmaceutical compositions thereof and a method of treating hypertension using such prodrugs are disclosed.

Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists

Novel tetrazolylphenylboronic acids, methods for their preparation, and their use in the syntheses of angiotensin II receptor antagonists are disclosed.