18039-42-4Relevant articles and documents
Tetrazoles: XLV. Amidoalkylation of 5-Substituted Tetrazoles
Myznikov,Esikov,Artamonova,Koldobskii
, p. 731 - 734 (2003)
Amidoalkylation of 5-aryl(hetaryl)tetrazoles with N-hydroxymethylamides of aliphatic and aromatic carboxylic acids occurs regioselectively and yields mainly 5-aryl(hetaryl)-2-acylaminomethyltetrazoles. These compounds are fairly stable in neutral media bu
Rectangular ZnO porous nano-plate assembly with excellent acetone sensing performance and catalytic activity
Giri, Arnab Kanti,Saha, Arka,Mondal, Aniruddha,Chandra Ghosh, Subhash,Kundu, Susmita,Panda, Asit Baran
, p. 102134 - 102142 (2015)
The controlled synthesis of a hierarchically assembled porous rectangular ZnO plate (2.5-3.5 μm length, 1.5-2.5 μm width and 100-150 nm thickness) from bulk ZnO without using any organic substrates, such as solvents/surfactants/structure-directing agents, is presented. The synthesized ZnO plates are single crystalline with exposed (1010) facets on the flat surface, porous and formed through the calcination of a hydrozincite [Zn5(CO3)2(OH)6] intermediate. A gas sensor based on the synthesized porous ZnO architecture exhibited high sensitivity towards acetone even in low concentration (S = 3.4 in 1 ppm acetone) with good selectivity. The ZnO nanostructured material as a heterogeneous catalyst also showed excellent catalytic activity for the synthesis of 5-substituted-1H-tetrazoles (yield = 94%). Both the activities are superior than those of other reported ZnO based acetone sensors and heterogeneous catalysts. We believe that the improved properties of the synthesized ZnO nanostructure is due to the exposed (1010) facets, and its porous and assembled structure, which provides a reasonably large accessible surface area, and facilitates diffusion and mass transport of gas or substrate molecules.
Tetrazoles: Calcium oxalate crystal growth modifiers
McMulkin, Calum J.,Massi, Massimiliano,Jones, Franca
, p. 2675 - 2681 (2015)
Molecules containing tetrazole substituents have become of interest due to their being bioisosteres of carboxylic acids and like their carboxylate counterparts, tetrazolate anions have been able to affect the crystal growth of barium sulphate and calcium carbonate. In this proof of principle study, we show that this behaviour also extends to calcium oxalate and therefore opens the possibility of using tetrazole-based additives for investigating mineralization processes of human pathological relevance. This journal is
Self-healing and moldable material with the deformation recovery ability from self-assembled supramolecular metallogels
Yan, Liwei,Gou, Shaohua,Ye, Zhongbin,Zhang, Shihong,Ma, Lihua
, p. 12847 - 12850 (2014)
A self-assembled non-covalent metallogel system with self-healing, deformation recoverable, moldable and bottom-up load-bearing properties was prepared using tetrazolyl derivatives and Pd(OAc)2. This journal is
Synthesis, characterization, and biological evaluation of oxadiazole derivatives bearing 5-phenyl-tetrazole as osteoclast differentiation inhibitors
Moon, Seong-Hee,Latif, Muhammad,Qasim, Muhammad,Choi, Sik-Won,Lee, Joo Yun,Byun, Byung Jin,Saeed, Aamer,Kim, Seong Hwan
, p. 2247 - 2253 (2015)
Novel oxadiazoles bearing 5-phenyl-tetrazole (5a-k) were designed and efficiently synthesized by treating 2-(5-phenyl-2H-tetrazole-2-yl)acetohydrazide (4) with aromatic carboxylic acids in POCl3, and their in vitro anti-osteoclastogenic activities were evaluated. In the cell-based osteoclast differentiation model, all compounds (5a-k) inhibited the formation of osteoclasts. In addition, the potential target molecules of compound 5 analogs were predicted with their chemical substructures via a web-based interface, and some of them were found to be related to osteoclast differentiation. Consequently, the scaffold containing oxadiazole-tetrazole in a single molecule and their analogs are of potential use in the design of novel anti-osteoclastogenic therapeutics.
Non-catalyzed addition of heterocyclic thiols and 5-substituted-1H-tetrazoles to vinyl ethers
Melnikova, Iuliia,Roh, Jaroslav,Kune?, Ji?í,Artamonova, Tatiana,Zevatskii, Yuri,Myznikov, Leonid
, p. 3842 - 3845 (2017)
The alkylation of 1-substituted 1H-tetrazole-5-thiols and 4-substituted 4 H-1,2,4-triazole-3-thiols with alkyl halides or sulfonates lead to the formation of S-alkylated products regardless of the substituent on the heterocycle. In this work, we found that substituted 1H-tetrazole-5-thiols and 4 H-1,2,4-triazole-3-thiols readily reacted with vinyl ethers in the absence of a catalyst to exclusively form N-substituted 1H-tetrazole-5(4H)-thiones and 1H-1,2,4-triazole-5(4H)-thiones, respectively. Furthermore, the reactions of 5-substituted-1H-tetrazoles with vinyl ethers under the same conditions selectively yielded 2,5-disubstitued tetrazoles.
Investigation of N-[(acyloxy)alkyl] ester as a prodrug model for drugs containing the phenyltetrazole moiety
Alexander,Renyer,Rork
, p. 893 - 897 (1994)
N-Acyloxyalkylation using 5-phenyltetrazole as a model compound was investigated as a general means of prodrug modification of the tetrazole ring with a view to change the physicochemical properties for improving biomembrane transport. Pivaloxymethylation
A novel route for the synthesis of 5-substituted 1-: H tetrazoles in the presence of polymer-supported palladium nanoparticles
Darbandizadeh Mohammad Abadi, Seyed Shahab Addin,Karimi Zarchi, Mohammad Ali
, p. 10397 - 10406 (2017)
A novel method for the synthesis of 5-substituted 1-H tetrazoles has been developed using one-pot tandem reactions of aryl halides with K4[Fe(CN)6] and sodium azide in the presence of cross-linked poly(4-vinylpyridine)-stabilized Pd(0) nanoparticles, [P4-VP]-PdNPs. The catalyst was characterized using various techniques such as FT-IR and UV-vis spectroscopy, AAS, TEM, FESEM, EDX analysis, XRD and XPS. The results confirm a good dispersion of palladium nanoparticles on the polymer support. The catalyst is reusable many times without a significant loss in its activity.
Efficient synthesis of tetrazole hemiaminal silyl ethers via three-component hemiaminal silylation
Xie, Ming-Sheng,Cheng, Xuan,Chen, Yang-Guang,Wu, Xiao-Xia,Qu, Gui-Rong,Guo, Hai-Ming
, p. 6890 - 6894 (2018)
An efficient route to construct 2,5-disubstituted tetrazole hemiaminal silyl ethers via one-pot three-component hemiaminal silylation of 5-substituted tetrazoles, aldehydes, and silyl triflates was developed. Diverse 2,5-disubstituted tetrazole hemiaminal silyl ethers were obtained with 37?:?63->99?:?1 regioisomeric ratios. The regioselectivities of this reaction were significantly affected by steric hindrance and the conjugation effects of substitutions on the 5-position of tetrazoles.
Dendron-functionalized Fe3O4 magnetic nanoparticles with palladium catalyzed CN insertion of arylhalide for the synthesis of tetrazoles and benzamide
Karimi Zarchi, Mohammad Ali,Darbandizadeh Mohammad Abadi, Seyed Shahab Addin
, p. 196 - 212 (2019)
A novel method for the one-pot synthesis of 5-substituted 1H-tetrazoles and Benzamide from arylhalide containing in situ CN insertion from inorganic salt source was accomplished in presence of a new magnetically catalyst, palladium on surface-modified Schiff-Base complex. K2[Ni(CN)4] plays a role of nontoxic inorganic cyanide source in arylhalide Nucleophilic substitution. The synthesized Pd-Schiff-Base@Fe3O4MNPs was characterized by various techniques such as FT-IR, TGA, SEM, VSM, XRD, TEM, ICP-AES, EDX, BET and XPS. The nano structure catalyst was easily recovered by external magnetic field and reused several times without noticeable loss of its catalytic activity. Leaching study of Pd-Schiff-Base@Fe3O4 MNPs shows palladium strong bonded to different active parts of catalyst surface. Heterogeneity of this catalyst has been examined using hot filtration and ICP-AES techniques.
