143771-90-8

Basic information

• Product Name: 8-Chloro-2,3,4,5-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5-oxo-1H-1-benzazepine-4-carboxylic acid ethyl ester
• Synonyms: 1H-1-Benzazepine-4-carboxylic acid, 8-chloro-2,3,4,5-tetrahydro-1-[(4-Methylphenyl)sulfonyl]-5-oxo-, ethyl ester;8-Chloro-2,3,4,5-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5-oxo-1H-1-benzazepine-4-carboxylic acid ethyl ester;8-Chloro-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine4-carboxylic acid ethtyl ester
• CAS NO: 143771-90-8
• Molecular Formula: C₂₀H₂₀ClNO₅S
• Molecular Weight: 422
• Mol File: 143771-90-8.mol

Chemical Properties

• Boiling Point: 583.5±60.0 °C(Predicted)
• Appearance: /
• Density: 1.355
• PKA: 10.09±0.20(Predicted)
• CAS DataBase Reference: 8-Chloro-2,3,4,5-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5-oxo-1H-1-benzazepine-4-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Chloro-2,3,4,5-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5-oxo-1H-1-benzazepine-4-carboxylic acid ethyl ester(143771-90-8)
• EPA Substance Registry System: 8-Chloro-2,3,4,5-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5-oxo-1H-1-benzazepine-4-carboxylic acid ethyl ester(143771-90-8)

Safety Data

• Hazardous Substances Data: 143771-90-8(Hazardous Substances Data)

Upstream product

• 42087-80-9 methyl 4-chloro-2-nitrobenzoate 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 29247-79-8 N-p-toluenesulfonyl-4-chloro-anthranilic acid methyl ester 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 38314-47-5 methyl 4-chloro-2-[N-(3-ethoxycarbonyl)propyl-N-p-toluenesulfonyl]aminobenzoate 

Downstream Products

• 271248-58-9 8-chloro-1-(2-methylbenzoyl)-1,2,3,4-tetrahydro-1-benzazepin-5-one 
• 116815-03-3 8-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 
• 38314-49-7 8-chloro-5-oxo-2,3,4,5-tetrahydro-1-p-toluenesulfonyl-1H-1-benzazepine 
• 60436-16-0 10-chloro-2,3-dihydro-4,5,6-trismethoxycarbonyl-7-hydroxy-1-p-tolylsulphonyl-1H-1-benzazonine 

Relevant articles and documents

Synthesis and diuretic activity of bicyclic fused heterocycles containing oxime-O-sulfonic acid moiety

In order to investigate the origin of the loop-type diuretic activity of M17055 (1), several variants (3-9) were designed and synthesized by modifying the quinolinone skeleton, and their diuretic activities were compared with the lead 1 and furosemide in dogs. It was found that the negative charge distribution pattern afforded by the dispositional arrangement of the 4- oxime-O-sulfonic acid and 1-N-acyl carbonyl moiety attached to the tetrahydropyridine ring system is inevitable for the development of the activity, which strongly supports the previously proposed model for the active site of the Na+-K+-2Cl- cotransporter. Also reported is the first synthesis of the dihydrothieno[3,2-b]pyridine-7(4H)-one ring system required in the synthesis of compound 9. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5- tetrahydro-1H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist

We previously reported a series of benzazepine derivatives as orally active nonpeptide arginine vasopressin (AVP) V2 receptor antagonists. After the lead structure OPC-31260 was structurally evaluated and optimized, the introduction of the 7-Cl moiety on the benzazepine and 2-CH3 on the aminobenzoyl moiety enhanced its oral activity. The new AVP-V2 selective antagonist OPC-41061 was determined to be a potent and orally active agent. Copyright (C) 1999 Elsevier Science Ltd.