38314-47-5

Basic information

• Product Name: methyl 4-chloro-2-{(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino}benzoate
• CAS NO: 38314-47-5
• Molecular Formula: C₂₁H₂₄ClNO₆S
• Molecular Weight: 453.9364
• Mol File: 38314-47-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 580.38°C at 760 mmHg
• Flash Point: 304.803°C
• Density: 1.3g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: methyl 4-chloro-2-{(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino}benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-chloro-2-{(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino}benzoate(38314-47-5)
• EPA Substance Registry System: methyl 4-chloro-2-{(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino}benzoate(38314-47-5)

Safety Data

• Hazardous Substances Data: 38314-47-5(Hazardous Substances Data)

Upstream product

• 2969-81-5 Ethyl 4-bromobutyrate 
• 29247-79-8 N-p-toluenesulfonyl-4-chloro-anthranilic acid methyl ester 
• 42087-80-9 methyl 4-chloro-2-nitrobenzoate 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 

Downstream Products

• 38314-48-6 8-chloro-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid methyl ester 
• 143771-90-8 8-Chloro-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester 
• 38314-49-7 8-chloro-5-oxo-2,3,4,5-tetrahydro-1-p-toluenesulfonyl-1H-1-benzazepine 
• 116815-03-3 8-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 
• 271248-58-9 8-chloro-1-(2-methylbenzoyl)-1,2,3,4-tetrahydro-1-benzazepin-5-one 
• 137984-96-4 1-(4-aminobenzoyl)-8-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 137984-93-1 8-chloro-1-(4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 137977-41-4 8-chloro-1-[4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 154890-41-2 8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 

Relevant articles and documents

Synthesis and diuretic activity of bicyclic fused heterocycles containing oxime-O-sulfonic acid moiety

In order to investigate the origin of the loop-type diuretic activity of M17055 (1), several variants (3-9) were designed and synthesized by modifying the quinolinone skeleton, and their diuretic activities were compared with the lead 1 and furosemide in dogs. It was found that the negative charge distribution pattern afforded by the dispositional arrangement of the 4- oxime-O-sulfonic acid and 1-N-acyl carbonyl moiety attached to the tetrahydropyridine ring system is inevitable for the development of the activity, which strongly supports the previously proposed model for the active site of the Na+-K+-2Cl- cotransporter. Also reported is the first synthesis of the dihydrothieno[3,2-b]pyridine-7(4H)-one ring system required in the synthesis of compound 9. (C) 2000 Editions scientifiques et medicales Elsevier SAS.