- Novel 4,5-dihydro-1H-pyrazole derivatives as potential succinate dehydrogenase inhibitors: design, synthesis, crystal structure, biological activity and molecular modeling
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Twenty-eight new 4, 5-dihydro-1H-pyrazole derivatives were designed, synthesized and characterized by IR, 1H NMR, 13C NMR and HRMS. The crystal structure of compound 2j was characterized by single crystal X-ray diffraction. Their ant
- Zhang, Tingting,Liu, Hui,Lu, Tong,Zhang, Guilan,Xiao, Tingting,Cheng, Wei,Wang, Jingwen,Jiang, Wenjing,Tang, Xiaorong
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- Design, synthesis, and antifungal activity evaluation of novel 2-cyano-5-oxopentanoic acid derivatives as potential succinate dehydrogenase inhibitors
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Two series of novel 2-cyano-5-oxopentanoic acid derivatives (1a?l, 2a?l) were designed, synthesized, and characterized by IR, 1H NMR, 13C NMR, and HRMS. Their in vitro antifungal activity against five plant pathogenic fungi were then
- Mai, Yong-zhan,Peng, Mi-jun,Tang, Xiao-rong,Wang, Xue-song
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- Design, synthesis and insecticidal activity of novel semicarbazones and thiosemicarbazones derived from chalcone
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Thirty semicarbazone and thiosemicarbazone derivatives (2a–w and 4a–g) from chalcones containing furan and thiophene ring were designed and synthesized. They were characterized by IR, 1H NMR, 13C NMR and HRMS. The crystal structure o
- Cheng, Wei,Xiao, Tingting,Qian, Weifeng,Lu, Tong,Zhang, Tingting,Tang, Xiaorong
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p. 3801 - 3809
(2020/03/23)
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- 2-(4-chlorphenyl) pyridine compound and application thereof in pesticide
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The invention relates to a 2-(4-chlorphenyl) pyridine compound and application thereof in pesticides, and belongs to the technical field of pesticides. The structural formula of the 2-(4-chlorphenyl) pyridine compound is as shown in formula (I), in the fo
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Paragraph 0064-0066
(2021/06/13)
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- 2, 3, 4, 6-tetrasubstituted pyridine compound and application thereof in pesticides
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The invention relates to a 2, 3, 4, 6-tetrasubstituted pyridine compound and application thereof in pesticides, which belong to the technical field of pesticides. The structural formula of the 2, 3, 4, 6-tetrasubstituted pyridine compound disclosed by the
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Paragraph 0064-0066
(2021/06/22)
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- Novel potent and selective DPP-4 inhibitors: Design, synthesis and molecular docking study of dihydropyrimidine phthalimide hybrids
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Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as antihyperglycemic agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in combination with other antidiabetic drugs. Methods: A novel series of dihydropyrimidine phthalimide hybrids was synthesized and evaluated for their in vitro and in vivo DPP-4 inhibition activity and selectivity using alogliptin as reference. Oral glucose tolerance test was assessed in type 2 diabetic rats after chronic treatment with the synthesized hybrids ± metformin. Cytotoxicity and antioxidant assays were performed. Additionally, molecular docking study with DPP-4 and structure activity relationship of the novel hybrids were also studied. Results: Among the synthesized hybrids, 10g, 10i, 10e, 10d and 10b had stronger in vitro DPP-4 inhibitory activity than alogliptin. Moreover, an in vivo DPP-4 inhibition assay revealed that 10g and 10i have the strongest and the most extended blood DPP-4 inhibitory activity compared to alogliptin. In type 2 diabetic rats, hybrids 10g, 10i and 10e exhibited better glycemic control than alogliptin, an effect that further supported by metformin combination. Finally, 10j, 10e, 10h and 10d had the highest radical scavenging activity in DPPH assay. Conclusions: Hybrids 10g, 10i and 10e are potent DPP-4 inhibitors which may be beneficial for T2DM treatment.
- Mourad, Ahmed A. E.,Khodir, Ahmed E.,Saber, Sameh,Mourad, Mai A. E.
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- 3-(4-chlorphenyl)-4, 5-dihydropyrazole derivative and application thereof in pesticides
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The invention relates to a 3-(4-chlorphenyl)-4, 5-dihydropyrazole derivative and an application thereof in pesticides, and belongs to the technical field of pesticides. The technical problem to be solved by the invention is to provide a novel compound which can be used as an agricultural bactericide and a seed germination accelerator. The structural formula of the compound is shown in the formulaI, wherein X is oxygen, sulfur or nitrogen and R is hydrogen, methyl, methoxyl, hydroxymethyl, chlorine or bromine. The compound has good inhibitory activity on plant pathogenic fungi, has a good promotion effect on germination of vegetable seeds and lays a good foundation for creation of new pesticides.
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Paragraph 0055-0057
(2020/04/17)
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- Studies of NMR Chemical Shifts of Chalcone Derivatives of Five-membered Monoheterocycles and Determination of Aromaticity Indices
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A series of the chalcone derivatives of the five-membered monoheterocyclic compounds, (E)-1-aryl-3-heteroarylpropen-1-ones, were prepared by aldol condensation of the corresponding aldehydes of thiophene, pyrrole, and furan with m- and p-substituted acetophenones. Similar condensation of the acetyl compounds of the heterocycles with m- and p-substituted benzaldehydes gave another series of the chalcone derivatives, (E)-1-heteroaryl-3-arylpropen-1-ones. The 13C chemical shift values (δC) of the chalcone derivatives were determined in order to find if they correlated with the Hammett σ values. A good correlation, especially for the β-C for both series, was found for the 13C chemical shift values (δC) of the chalcone derivatives with the Hammett σ values. The chemical shift values of the β-C of the heterocyclic compounds were plotted against those of the benzene derivatives. The resulting slopes were found to be close to the values of the aromaticity indices.
- Jeong, Eun Jeong,Lee, In-Sook Han
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p. 668 - 673
(2019/07/12)
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- N1-benzenesulfonyl-2-pyrazoline hybrids in neurological disorders: Syntheses, biological screening and computational studies
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A novel series of 1,3,5-trisubstituted-2-pyrazolines (5a-5t) was prepared via Claisen Schmidt condensation, followed by heterocyclization with hydrazine hydrate, substitution of N1 hydrogen of 2-pyrazoline nucleus with 4-chlorobenzenesulfonylchloride, app
- Tripathi, Avinash C.,Upadhyay, Savita,Paliwal, Sarvesh,Saraf, Shailendra K.
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p. 126 - 148
(2018/02/14)
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- Derivatives of 4,5-dihydro (1H) pyrazoles as possible MAO-A inhibitors in depression and anxiety disorders: synthesis, biological evaluation and molecular modeling studies
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A series of 1,3,5-trisubstituted-2-pyrazoline derivatives (3a–3t) were synthesized in appreciable yields by substituting N1 position of 2-pyrazoline nucleus with 4-nitrobenzenesulfonylchloride using conventional and microwave assisted synthetic approaches
- Tripathi, Avinash C.,Upadhyay, Savita,Paliwal, Sarvesh,Saraf, Shailendra K.
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p. 1485 - 1503
(2018/03/29)
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- Ultrasound-mediated synthesis, biological evaluation, docking and in vivo acute oral toxicity study of novel indolin-2-one coupled pyrimidine derivatives
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The work reports ultrasound-mediated greener synthesis of 11 novel 3-(4-(4-chlorophenyl)-6-(substituted phenyl/heteryl)pyrimidin-2-ylimino)indolin-2-one (7a–7k) derivatives. The synthesized derivatives were evaluated for their in vitro anticancer activity against a panel of selected human cancer cell lines of breast (MCF-7), cervix (HeLa), prostate (PC-3) and lung (A-549). Among the tested compounds, 7b exhibited most promising in vitro anticancer activity against HeLa, PC-3 and A-549 with GI50 value 15.38, 19.67 and 4.37?μM, respectively. The compounds (7a–7k) were also screened for induction of apoptosis and morphological changes in cancer cells at their GI50 concentration. The treatment of HeLa, PC-3 and A549 cancer cells with 7b and treatment of MCF-7 cancer cells with 7h showed apoptosis and morphological changes such as cell shrinkage, cell wall deformation and reduced number of viable cells. The compound 7b has shown almost 5.00 times more selectivity for PC-3 cancer cell lines in comparison to the RWPE-1 normal prostate epithelial cells. Molecular docking study has been carried out, which replicates results of biological activity in cases of initial hits 7b, 7c and 7d, suggesting that these compounds have a potential to become lead molecules in the drug discovery process. In silico ADMET study was performed for predicting pharmacokinetic properties and toxicity profile of the synthesized compounds and expressed good oral drug-like behaviour. An in vivo acute oral toxicity study was performed using Swiss albino mice for the most active compounds 7b and 7c, and results indicate that the compounds are non-toxic in nature.
- Nikalje, Anna Pratima G.,Tiwari, Shailee V.,Sangshetti, Jaiprakash N.,Damale, Manoj D.
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p. 3031 - 3059
(2018/02/06)
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- A regioselective and convenient one-pot multicomponent synthesis of 9-amino-3,5-diaryl-4,9-dihydro-5H-[1,2,4]triazolo[5,1-c][1,2,4]triazepine-8-thiol
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An efficient and environment-friendly procedure for the synthesis of a new series of nitrogen bridge-head [1,2,4]triazolo[5,1-c][1,2,4]triazepine derivatives through one-pot three-component reaction of polyfunctional triazole with aromatic aldehydes and acetophenone derivatives using alcoholic sodium hydroxide solution. The same new products were prepared in classical route through reaction of triazole with the corresponding chalcones under the same conditions.
- Moustafa, Amr Hassan,Amer, Amer Anwar
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p. 1102 - 1109
(2017/05/25)
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- An expeditious one-pot microwave facilitated versus conventional syntheses: In vivo biological screening and molecular docking studies of some 3,5-disubstituted-4,5-dihydro-(1H)-pyrazole derivatives
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A series of 3,5-disubstituted-2-pyrazoline derivatives (2a-2t) were synthesized by reacting different aromatic/heteroaromatic aldehydes and ketones, in a two-step reaction through Claisen Schmidt condensation, followed by cyclization of the resulted chalc
- Tripathi, Avinash C.,Upadhyay, Savita,Paliwal, Sarvesh,Saraf, Shailendra K.
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p. 390 - 406
(2016/02/19)
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- 1-(2-furyl)-3-(4-substituted phenyl)propylene derivative as well as preparation method and application thereof
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The invention provides a 1-(2-furyl)-3-(4-substituted phenyl)propylene derivative as well as a preparation method and application thereof. The derivative has a structural formula (I) shown in the following description; in the structural formula (I), R is
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Paragraph 0040; 0041
(2016/10/07)
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- 3-(2-furyl)propenol derivative as well as preparation method and application thereof
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The invention provides a 3-(2-furyl)propenol derivative as well as a preparation method and application thereof. The derivative has a structural formula (I) shown in the following description; in the structural formula (I), R is a fluorine atom, a chlorin
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Paragraph 0039; 0040
(2016/10/09)
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- Semicarbazone compound and preparation method and application thereof
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The invention provides a semicarbazone compound and a preparation method and application thereof. The structural general formula of the compound is shown in the description, wherein the R represents fluorine atoms, chlorine atoms, bromine atoms, iodine at
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Paragraph 0040; 0041
(2016/10/31)
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- Study of Regiochemical Trends During the Synthesis of Furan and 5-(p-chlorophenyl)Furan Containing Novel Spiropyrrolidine Library Through 1,3-dipolar Cycloaddition Reactions
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A new class of functionalized furan and 5-(p-chlorophenyl)furan containing spiropyrrolidines has been synthesized in moderate to excellent yields by the one-pot, three-component 1,3-dipolar cycloaddition reaction of in situ generated azomethine ylides with various furan/aryl furan-substituted chalcones as dipolarophiles. The effect of electron deficient substituents at the fifth position of the furan ring in the chalcone on the regiochemistry of the cycloaddition formed was studied. The structures of the newly synthesized cycloaddicts were proved by analytical and spectral data.
- Mallya, Sahana,Kalluraya, Balakrishna,Jois, H. S. Vidyashree
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p. 1859 - 1865
(2016/11/23)
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- Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure-activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor
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A series of pyrazoline derivatives (5) were synthesized in 92-96% yields from chalcones (3) and hydrazides (4). Subsequently, topo-I and IIα-mediated relaxation and antiproliferative activity assays were evaluated for 5. Among the tested compounds, 5h had
- Ahmad, Pervez,Woo, Hyunjung,Jun, Kyu-Yeon,Kadi, Adnan A.,Abdel-Aziz, Hatem A.,Kwon, Youngjoo,Rahman, A.F.M. Motiur
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p. 1898 - 1908
(2016/04/05)
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- Novel pyrazoline derivatives and the use thereof
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The present invention relates to a novel pyrazoline derivative compound, a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for preventing or treating cancer, containing the pyrazoline derivative compound or the pharmaceutically
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Paragraph 0101; 0103-0104; 0121
(2016/12/01)
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- 1-Acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles: Exhibiting anticancer activity through intracellular ROS scavenging and the mitochondria-dependent death pathway
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A series of 17 analogs of 1-acetyl-4,5-dihydro(1H)pyrazoles (JP-1 to JP-17) bearing two aromatic rings at positions 3 and 5, either of which ought to be heterocyclic, were synthesized and evaluated for their anti-proliferative potential against breast cancer (MCF-7 and T-47D) and lung cancer (H-460 and A-549) cell lines for the first time. JP-1-7, -10, -11, -14, and -15 were observed to exhibit significant anti-proliferative activity against MCF-7 cells. Some notions about structure-activity relationships are reported. The investigated compounds were found to lower the intracellular reactive oxygen species in the H2DCFDA assay and also caused mitochondria-dependent cell death in the MCF-7 cell line, indicating a plausible mechanism of their anticancer effect. Analogs of 1-acetyl-4,5-dihydro(1H)pyrazoles (JP-1-17) were synthesized and evaluated for their anti-proliferative activity in four cancer cell lines and for their intracellular ROS scavenging properties. An attempt was made to determine the mitochondrial membrane potential of MCF-7 cells treated with JP-1 and -14, aiming to elucidate the mechanism by which proliferation was curbed.
- Alex, Jimi M.,Singh, Sandeep,Kumar, Raj
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p. 717 - 727
(2016/02/18)
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- Synthesis and biological evaluation of some new 4-aryl-1-(4,6-diaryl pyrimidine)-2-azetidinone by conventional and microwave methods and their biological activities
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4-Aryl-1-(4,6-diaryl pyrimidine)-2-azetidinone/4-aryl-3-chloro-1-(4,6- diaryl pyrimidine)-2-azetidinone were prepared by reaction of appropriate 2-(methoxy phenylideneamino)-4-diaryl pyrimidine (Schiff base) and acetyl chloride/chloroacetylchloride in dim
- Sharma, Sharda,Jain, Renuka,Sharma, Vikas,Chawla, Chetali
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p. 221 - 229
(2013/06/04)
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- Synthesis and cdc25B inhibitory activity evaluation of chalcones
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A library of sixty-five chalcones was prepared for screening against the protein phosphatase, cdc25B. From this library, thirteen compounds were found having good inhibitory activity. Two compounds have excellent activity and can be used for the design of
- Zhao, Fei,Zhao, Qing-Jie,Zhao, Jing-Xia,Zhang, Da-Zhi,Wu, Qiu-Ye,Jin, Yong-Sheng
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p. 206 - 214
(2013/07/26)
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- Microwave assisted synthesis and antibacterial activity of chalcone derivatives
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Chalcone derivatives have been synthesized by equimolar reactions between substituted aldehydes and substituted acetophenones in basic medium by using conventional and microwave assisted technique. These compounds are characterized by FTIR and 1H NMR spectra. Before characterization purity of these compounds has been checked by thin-layer chromatography method. These synthesized compounds have been screened for their antibacterial (E. coli, S. aureus) activities in different concentrations. The results showed that the chalcone derivatives are better at inhibiting growth of both types of bacteria (Gram negative and Gram positive) compared to chloramphenicol.
- Yadav, Khushbu,Sharma, Abha,Srivastava, J. N.
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p. 5779 - 5781,3
(2020/09/14)
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- Synthesis and evaluation of some novel [1,2,4]triazolo[1,5-α] pyrimidine derivatives for anticancer activity
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A series of 7-(4-chlorophenyl)-2-phenyl-1,7-dihydro [1,2,4] triazolo [1,5α] pyrimidine 4a-l have been synthesized and evaluated for anticancer activity. The newly synthesized compounds have been characterized by IR, 1H NMR and elemental analyse
- Pattan, Shashikant,Hole, Mangesh,Pattan, Jayshri,Dengale, Santosh,Shinde, Hemlata,Muluk, Rekha,Nirmal, Sunil,Jadhav, Ravindra
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experimental part
p. 774 - 779
(2012/07/03)
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- Design, synthesis, and bioactivities screening of a diaryl ketone-inspired pesticide molecular library as derived from natural products
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Three natural products, 1,5-diphenylpentan-1-one, 1,5-diphenylpent-2-en-1-one, and 3-hydroxy-1,5-diphenylpentan-1-one, with good insecticidal activities were extracted from Stellera chamaejasme L. Based on their shared diaryl ketone moiety as 'pharmacophores', a series of diaryl ketones were synthesized and tested for insecticidal activity, acetylcholinesterase inhibitory activity, and antifungal activity. All synthesized compounds showed poor insecticidal and acetylcholinesterase inhibitory activities. Compound III with a furyl ring showed strong activities against plant pathogenic fungi. The IC50 of compound (E)-1-(2,4-dichlorophenyl)-3-(furan-2-yl)- -prop-2-en-1-one (III2) was 1.20mg/L against Rhizoctonia solani, suggesting its strong potential as a novel antifungal drug.
- Zhang, Hong,Jin, Hong,Ji, Lan-Zhu,Tao, Ke,Liu, Wei,Zhao, Hao-Yu,Hou, Tai-Ping
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experimental part
p. 94 - 100
(2012/06/01)
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- Synthesis of 1,3,5-trisubstituted pyrazolines as antimicrobial. and antiinflammatory agents
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A series of pyrazolines (2a-j) have been synthesized and evaluated for their antimicrobial and antiinflammatory activities. The structures of the synthesized compounds have been confirmed on the basis of physical and spectral data. Compounds 2b, 2c, 2e and 2g have shown moderate antibacterial activity. None of the synthesized compounds showed antifungal activity. Compounds 2b and 2c exhibited significant antiinflammatory activity.
- Nuthana,Harinadha Babu,Madhava Reddy
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p. 283 - 284
(2013/09/24)
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- Synthesis and anti-bacterial activity of some heterocyclic chalcone derivatives bearing thiofuran, furan, and quinoline moieties
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36 Novel heterocyclic chalcone derivatives were synthesized and tested for their anti-bacterial activity. Some compounds presented good anti-microbial activities against Gram-positive bacteria (including the multidrug-resistant clinical isolates). This cl
- Zheng, Chang-Ji,Jiang, Sheng-Ming,Chen, Zhen-Hua,Ye, Bai-Jun,Piao, Hu-Ri
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experimental part
p. 689 - 695
(2012/06/01)
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- Potassium-tertiary butoxide-assisted addition of thioglicolic acid to chalcone derivatives under solvent-free conditions
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A series of chalcone derivatives containing thioglicolic acid (4a-j) was prepared by addition of thioglicolic acid to the chalcones (3a-j) in the presence of KOt-Bu under solvent-free conditions. The mechanistic pathway of the reaction can be explained by
- Ceylan, Mustafa,Guerdere, Meliha Burcu,Gezegen, Hayreddin,Budak, Yakup
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experimental part
p. 2598 - 2606
(2010/10/03)
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- Synthesis and biological evaluation of some novel 1, 3, 5-trisubstituted pyrazolines
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A new series of chalcones (3a-j) were synthesized by condensation of simple aldehydes with substituted acetophenones in presence of alkali. The resulted chalcones upon cyclization in presence of glacial acetic acid with isoniazid (INH) will yields the title compounds (4a-j). The newly synthesized compounds were assigned on the basis of IR, 1H NMR, and Mass spectral data. All the final compounds were evaluated for their in vitro antimicrobial activity.
- Revanasiddappa,Rao, R Nagendra,Subrahmanyam,Satyanarayana
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experimental part
p. 295 - 298
(2011/01/03)
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- Screening of biological activities of a series of chalcone derivatives against human pathogenic microorganisms
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In an effort to develop new antimicrobial agents, a series of chalcone derivatives, 3-60, were prepared by Claisen-Schmidt condensation of appropriate acetophenones and 2-furyl methyl ketones with appropriate aromatic aldehydes, furfural, and thiophene-2-carbaldehyde in an aqueous solution of NaOH and EtOH at room temperature. The synthesized compounds were characterized by means of their IR- and NMR-spectral data, and elemental analysis. All compounds were tested for their antibacterial and antifungal activities by the disc diffusion method. For the most active compounds, also minimum inhibitory concentrations (MICs) were determined.
- Karaman, Isa,Gezegen, Hayreddin,Guerdere, M. Burcu,Dingil, Alparslan,Ceylan, Mustafa
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experimental part
p. 400 - 408
(2010/09/04)
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- Catalytic transfer reduction of electron deficient alkenes and an imine using potassium formate and catalytic palladium acetate
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Chemoselective reduction of α, β-unsaturated cyanostannyl esters, ketones and an imine with potassium formate as hydrogen donor and palladium acetate as homogeneous catalyst in DMF was observed to proceed readily with saturation of C-C and C-N double bond
- Bhuiyan, Md Mosharef Hossain
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p. 377 - 380
(2007/10/03)
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- Ultrasound promoted synthesis of α,α'-bis(substituted furfurylidene) cycloalkanones and chalcones
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Condensation of furfural with cycloalkanones and substituted acetophenones catalysed by potassium hydroxide results α,α'- bis(substituted furfurylidene) cycloalkanones and chalcones in high yield under ultrasound irradiation in 4-50 min.
- Li, Ji-Tai,Chen, Guo-Feng,Wang, Jian-Xin,Li, Tong-Shuang
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p. 965 - 971
(2007/10/03)
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- Convenient synthesis of α,α1-bis (substituted furfurylidene) cycloalkanones and chalcones under microwave irradiation
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Condensation of furfural with cycloalkanones and substituted acetophenones catalyzed by solid NaOH results in α,α1-bis (substituted furfurylidene) cycloalkanones and chalcones in high yield under microwave irradiation for a duration of 2 minute
- Babu,Perumal
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p. 3677 - 3682
(2007/10/03)
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- Synthesis of 3-Cyano-2-methylpyridines Substituted with Heteroaromatics
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A series of title compounds were easily prepared by the sonication of α,β-unsaturated carbonyl compound in acetonitril in the presence of potassium t-butoxide.
- Shibata, Katsuyoshi,Katsuyama, Isamu,Matsui, Masaki,Muramatsu, Hiroshiga
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p. 161 - 165
(2007/10/02)
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- Photodimerisation of Aryl β-(2-Furyl)vinyl Ketones
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Aryl β-(2-furyl)vinyl ketones (1-4) on photoirradiation gave the corresponding dimers (5-8) having cis-anti-cis configuration.The stereochemistry of these dimers has been established by reduction of 6 to diol 13, which upon subsequent dehydration gave the
- Dureja, P.,Sharma, Sunila,Walia, S.,Mukerjee, S. K.
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p. 1173 - 1175
(2007/10/02)
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- Studies of Substituent Effects by Carbon-13 NMR Spectroscopy. Thiophene and Furan Chalcone Analogues
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13C NMR spectra of 39 thiophene and furan chalcone analogues in CDCl3 solutions are reported.The effect of substituents on the 13C chemical shifts in the phenyl and in the 5-membered rings is discussed. 13C NMR shifts are correlated with Hammett parameter
- Musumarra, Giuseppe,Ballistreri, Francesco P.
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p. 384 - 391
(2007/10/02)
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