- SUBSTITUTED HETEROCYCLIC COMPOUNDS
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The present invention relates to substituted heterocyclic compounds of Formula I or XI: or pharmaceutically acceptable salts or N-oxides or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are histamine II4 receptor inhibitors useful in the treatment of histamine II4 receptor-associated conditions or diseases or disorders including, for example, inflammatory diseases or disorders, pruritus, and pain.
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Page/Page column 102
(2010/10/03)
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- Therapeutically active diarylpropylamines; their pharmaceutically acceptable salts; a method for their preparation and method for their use
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The invention relates to novel compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers, the racemic mixture and the individual enantiomers. The compounds have anticholinergic activity, and the invention also relates to the compounds of Formula (I), the use of the compounds of Formula (I) for preparing anticholinergic drugs, the use of the compounds of Formula (I) for treating urinary tract incontinence, and methods for preparing the compounds of Formula (I).
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- Simple synthesis of arylsuccinic acids
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Alkylation of arylacetonitriles with potassium chloroacetate proceeds selectively leading to 3-cyano-3-arylpropionic acids, which are directly hydrolyzed to arylsuccinic acids.
- Makosza,Marcinowicz
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p. 1311 - 1312
(2007/10/03)
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- Irreversible dopamine-β-hydroxylase inhibitors
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Potent, irreversible dopamine-β-hydroxylase inhibitors having the Formula: STR1 which are useful to inhibit dopamine-β-hydroxylase activity, pharmaceutical compositions including these inhibitors or 2-cyano-2-phenethylamine, and methods of using these inhibitors or 2-cyano-2-phenethylamine to inhibit dopamine-β-hydroxylase activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.
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