Process for the preparation of an intermediate of a benzo[a]quinolizinone derivative
The invention is concerned with a process for the preparation of a benzo[a]quinolizinone derivative of the formula STR1 by reacting a compound of the formula STR2 wherein X is halogen and Ph is phenyl, with carbon monoxide in the presence of a carbonylati
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(2008/06/13)
An Expedient Route to the Tricyclic Pyridone Derivative Ro 41-3696, a Novel Non-Benzodiazepine Sleep Inducer
A short, technical synthesis of (S)-10-chloro-1-(3-ethoxypyrrolidin-1-yl)-3-phenyl-6,7-dihydro-4H-benzoquinolizin-4-one (1) from 2-(4-chlorophenyl)ethylamine (2) is described.
The compound (S)-1-[(10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quino-lizin-1-yl)carbonyl]-3-ethoxypyrrolidine of the formula STR1 which has valuable pharmacological properties, is described. In particular, the compound of formula I has a non-sedatin
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(2008/06/13)
Tricyclic pyridine derivatives and pharmaceutical compositions
Compounds of the formula STR1 or a pharmaceutically acceptable acid addition salt of a compound of formula I which has one or more basic substituents, are described. The compounds of formula I possess pronounced muscle relaxant, sedative-hypnotic, anticonvulsive and anxiolytic properties and have low toxicity.
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(2008/06/13)
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