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143949-72-8

3-(1H-Benzoimidazol-2-yl)-Propionic Acid Hydrazide is a chemical compound that belongs to the class of propionic acid derivatives and features a benzoimidazole ring. It has been studied for its potential pharmaceutical applications, including as an antitumor agent and an antioxidant. Additionally, it has shown promise as a therapeutic agent for neurological disorders due to its ability to cross the blood-brain barrier. Further research is necessary to fully explore its pharmacological properties and potential uses.

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  • 143949-72-8 Structure

  • Basic information

    1. Product Name: 3-(1H-BENZOIMIDAZOL-2-YL)-PROPIONIC ACID HYDRAZIDE
    2. Synonyms: 3-(1H-benzimidazol-2-yl)propanohydrazide(SALTDATA: FREE);CHEMBRDG-BB 5790582;3-(1H-BENZOIMIDAZOL-2-YL)-PROPIONIC ACID HYDRAZIDE;3-(1H-BENZIMIDAZOL-2-YL)PROPANOHYDRAZIDE
    3. CAS NO:143949-72-8
    4. Molecular Formula: C10H12N4O
    5. Molecular Weight: 204.23
    6. EINECS: N/A
    7. Product Categories: pharmacetical
    8. Mol File: 143949-72-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 576.6°C at 760 mmHg
    3. Flash Point: 302.5°C
    4. Appearance: /
    5. Density: 1.325g/cm3
    6. Vapor Pressure: 2.7E-13mmHg at 25°C
    7. Refractive Index: 1.676
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 3-(1H-BENZOIMIDAZOL-2-YL)-PROPIONIC ACID HYDRAZIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-(1H-BENZOIMIDAZOL-2-YL)-PROPIONIC ACID HYDRAZIDE(143949-72-8)
    12. EPA Substance Registry System: 3-(1H-BENZOIMIDAZOL-2-YL)-PROPIONIC ACID HYDRAZIDE(143949-72-8)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36
    3. Safety Statements: 26
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 143949-72-8(Hazardous Substances Data)

143949-72-8 Usage

Uses

Used in Pharmaceutical Industry:
3-(1H-Benzoimidazol-2-yl)-Propionic Acid Hydrazide is used as an antitumor agent for its potential to combat cancer cells. It is being investigated for its ability to inhibit tumor growth and progression, making it a candidate for cancer treatment.
Used in Antioxidant Applications:
As an antioxidant, 3-(1H-Benzoimidazol-2-yl)-Propionic Acid Hydrazide is utilized to counteract oxidative stress and protect cells from damage caused by reactive oxygen species, which can contribute to various diseases and aging.
Used in Neurological Disorder Treatment:
3-(1H-Benzoimidazol-2-yl)-Propionic Acid Hydrazide is used as a potential therapeutic agent for the treatment of neurological disorders. Its ability to cross the blood-brain barrier makes it a candidate for drugs targeting the central nervous system, potentially aiding in the treatment of conditions such as Alzheimer's, Parkinson's, and other neurodegenerative diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 143949-72-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,9,4 and 9 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 143949-72:
(8*1)+(7*4)+(6*3)+(5*9)+(4*4)+(3*9)+(2*7)+(1*2)=158
158 % 10 = 8
So 143949-72-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N4O/c11-14-10(15)6-5-9-12-7-3-1-2-4-8(7)13-9/h1-4H,5-6,11H2,(H,12,13)(H,14,15)

143949-72-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(1H-benzimidazol-2-yl)propanehydrazide

1.2 Other means of identification

Product number -
Other names 1H-Benzimidazole-2-propanoic acid,hydrazide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:143949-72-8 SDS

143949-72-8Relevant articles and documents

Synthesis of some hydroxamic acid derivatives of benzimidazole and their antibacterial and antifungal activities

Gunes,Cosar

, p. 1045 - 1048 (2007/10/02)

A number of 1H-benzimidazole-2-propanoic acid derivatives have been synthesized by Phillips method, and their antibacterial and antifungal activities have been tested. The chemical structures of the synthesized compounds were elucidated by spectroscopic (IR, NMR, mass) and elementary analysis. Investigation of antimicrobial activity of the compounds was done by agar dilution technique using bacteria (Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Mycobacterium smegmatis ATCC 607) and yeast-like fungi (Candida albicans, Candida tropicalis, Candida pseudotropicalis, Candida kruzei, Candida globrata). Among the compounds tested N-hydroxy-3-(1H-benzimidazol-2-yl)-propionamide (Compound 6) showed considerable activity against both Candida albicans and Candida tropicalis.

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