29518-68-1

Basic information

• Product Name: BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL&
• Synonyms: 2-(1H-Benzo[d]iMidazol-2-yl)ethanaMine;2-(2-Aminoethyl)benzimidazole;2-(Aminoethyl)-1H-benzimidazole;1H-Benzimidazole-ethanamine diHCl;BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL&;1H-BENZIMIDAZOLE-ETHANAMINE . 2HCL;1H-BENZIMIDAZOLE-ETHANAMINE DIHYDROCHLORIDE;1H-Benzimidazole-2-ethanamine(9CI)
• CAS NO: 29518-68-1
• Molecular Formula: C₉H₁₁N₃
• Molecular Weight: 234.12562
• Product Categories: BENZIMIDAZOLE;Olefination;Supported Reagents;Supported Synthesis;Wittig Reagents;Wittig ReagentsC-C Bond Formation
• Mol File: 29518-68-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 160℃
• Boiling Point: 400°Cat760mmHg
• Flash Point: 224.5°C
• Appearance: /
• Density: 1.225
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 11.82±0.10(Predicted)
• CAS DataBase Reference: BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL&(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL&(29518-68-1)
• EPA Substance Registry System: BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL&(29518-68-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 29518-68-1(Hazardous Substances Data)

Usage

Uses

Polymer-supported Wittig reagent for clean olefinations of carbonyl compounds.

Upstream product

• 4414-88-4 1H-benzimidazol-2-acetonitrile 
• 95-54-5 1,2-diamino-benzene 
• 4499-07-4 2-(1H-benzo[d]imidazol-2-yl)ethanamine dihydrochloride 
• 143949-72-8 3-(1H-benzoimidazol-2-yl)-propionic acid hydrazide 
• 6315-23-7 3-(1H-benzimidazol-2-yl)-propionic acid ethyl ester 
• 107-95-9 3-amino propanoic acid 
• 107313-47-3 N-(2-(1H-benzimidazole-2-yl)ethyl)benzamide 
• 4216-52-8 [2-(1H-benzoimidazol-2-yl)-ethyl]-carbamic acid ethyl ester 

Downstream Products

• 406726-70-3 7-[2-(1H-Benzoimidazol-2-yl)-ethylcarbamoyl]-heptanoic acid methyl ester 

Relevant articles and documents

Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives

In this study, a series of compounds derived from 4-methoxy-1H-isoindole-1,3(2H)-dione, potential ligands of phosphodiesterase 10A and serotonin receptors, were investigated as potential antipsychotics. A library of 4-methoxy-1H-isoindole-1,3(2H)-dione derivatives with various amine moieties was synthesized and examined for their phosphodiesterase 10A (PDE10A)-inhibiting properties and their 5-HT1A and 5-HT7 receptor affinities. Based on in vitro studies, the most potent compound, 18 (2-[4-(1H-benzimidazol-2-yl)butyl]-4-methoxy-1H-isoindole-1,3(2H)-dione), was selected and its safety in vitro was evaluated. In order to explain the binding mode of compound 18 in the active site of the PDE10A enzyme and describe the molecular interactions responsible for its inhibition, computer-aided docking studies were performed. The potential antipsychotic properties of compound 18 in a behavioral model of schizophrenia were also investigated.

BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS

The present invention provides compounds having formula (I) wherein n, p, q and r are each independently selected from 0 or 1; a, b, c, and d each independently represents a carbon or nitrogen atom, with the proviso that no more than two of a, b, c, and d are nitrogen atoms; Y and Y' each independently represents 1-4 optional substituents selected from alkyl, alkoxy, halo, -CF3, and -C(O)OH; R, R, R and R are H or specified substituents; R, R, R, R, R, R, R and R are independently selected from H or C1-C3 alkyl; or a biolabile ester thereof, or a pharmaceutically acceptable salt thereof. Also provided are methods of using these compounds for treating vitronectin-mediated disorders, e.g., cancer, retinopathy, artherosclerosis, vascular restenosis, and osteoporosis.

Heterocyclization of the 2-aminoalkyl (and aryl) benzimidazoles under phase transfer catalysis conditions

A number of new imidazolo (pyrazino and diazepino) benzimidazoles have been prepared by reaction between 2-aminoalkyl (and aryl)benzimidazoles and dibromoalkanes Br-(CH2)n-Br under phase transfer catalysis conditions.These products have been characterized by 1H NMR, IR, MS and their microanalysis. --- Key words: heterocyclization / benzimidazole / diazepinobenzimidazole / benzimidazolo benzodiazepin