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2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

14396-89-5

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14396-89-5 Usage

Type of compound

heterocyclic

Core structure

isoindoline-1,3-dione

Substituent

but-3-yn-2-yl

Usage

organic synthesis and medicinal chemistry research

Value

valuable tool for drug and material development

Potential applications

pharmaceutical industry

Ongoing research

synthesis, characterization, and potential uses in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 14396-89-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,3,9 and 6 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 14396-89:
(7*1)+(6*4)+(5*3)+(4*9)+(3*6)+(2*8)+(1*9)=125
125 % 10 = 5
So 14396-89-5 is a valid CAS Registry Number.

14396-89-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-but-3-yn-2-ylisoindole-1,3-dione

1.2 Other means of identification

Product number -
Other names QC-5306

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14396-89-5 SDS

14396-89-5Relevant articles and documents

An Enzymatic Platform for Primary Amination of 1-Aryl-2-alkyl Alkynes

Liu, Zhen,Qin, Zi-Yang,Zhu, Ledong,Athavale, Soumitra V.,Sengupta, Arkajyoti,Jia, Zhi-Jun,Garcia-Borràs, Marc,Houk,Arnold, Frances H.

supporting information, p. 80 - 85 (2022/01/08)

Propargyl amines are versatile synthetic intermediates with numerous applications in the pharmaceutical industry. An attractive strategy for efficient preparation of these compounds is nitrene propargylic C(sp3)-H insertion. However, achieving this reacti

KCNT1 INHIBITORS AND METHODS OF USE

-

Page/Page column 65-66, (2021/10/02)

The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.

1-((1H-PYRAZOL-4-YL)METHYL)-3-(PHENYL)-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS GPR139 ANTAGONISTS FOR THE TREATMENT OF E.G. DEPRESSION

-

Paragraph 000414-000415, (2021/11/26)

The present invention refers to compounds of formula (I). The present invention also relates to compounds of formula (I) for use as G Protein coupled Receptor 139 (GPR139) antagonists in methods of medical treatment of e.g. depression, Alzheimer's disease

Synthesis and bioactivities of novel N-(4-(2-Aryloxythiazol-5-yl)but-3-yn- 2-yl)benzamides

Zhu, Youquan,Liu, Pei,Wang, Danyang,Zhang, Jin,Cheng, Jie,Ma, Yuan,Zou, Xiaomao,Yang, Huazheng

, p. 173 - 181 (2013/08/24)

A series of novel N-(4-(2-aryloxythiazol-5-yl)but-3-yn-2-yl)benzamide derivatives were designed and synthesized. Their structures were identified by 1H NMR and elemental analyses. Preliminary bioassays indicated that some title compounds provided >80% control of Sclerotinia sclerotiorum at 50 μg/mL and >70% herbicidal activities against B. campestris at 100 μg/mL. Their structure-activities relationships were also discussed. A series of novel N-(4-(2-aryloxythiazol-5-yl)but-3-yn-2-yl)benzamide derivatives were designed and synthesized. Some of them provided >80% control of Sclerotinia sclerotiorum at 50 μg/mL and >70% herbicidal activities against B. campestris at 100 μg/mL. Copyright

Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process

Kolleth, Amandine,Christoph, Sarah,Arseniyadis, Stellios,Cossy, Janine

supporting information, p. 10511 - 10513,3 (2020/09/02)

The non-enzymatic kinetic resolution of diversely substituted primary propargylic amines is reported featuring a highly selective acetyl transfer using (1S,2S)-1 in conjunction with AliquatTM 336, affording the corresponding enantio-enriched N-

NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME

-

Page/Page column 29, (2008/06/13)

The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy) thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors

Gu, Yu Gui,Weitzberg, Moshe,Clark, Richard F.,Xu, Xiangdong,Li, Qun,Zhang, Tianyuan,Hansen, T. Matthew,Liu, Gang,Xin, Zhili,Wang, Xiaojun,Wang, Rongqi,McNally, Teresa,Camp, Heidi,Beutel, Bruce A.,Sham, Hing L.

, p. 3770 - 3773 (2007/10/03)

A structurally novel acetyl-CoA carboxylase (ACC) inhibitor is identified from high-throughput screening. A preliminary structure-activity relationship study led to the discovery of potent dual ACC1/ACC2 and ACC2 selective inhibitors against human recombinant ACC1 and ACC2. Selective ACC2 inhibitors exhibited IC50 1000-fold selectivity against ACC1. (S)-Enantiomer 9p exhibited high ACC2 activity and lowered muscle malonyl-CoA dose-dependently in acute rodent studies, whereas (R)-enantiomer 9o was weak and had no effect on the malonyl-CoA level.

Synthesis of substituted Se-phenyl selenocarboxylates from terminal alkynes

Tiecco, Marcello,Testaferri, Lorenzo,Temperini, Andrea,Bagnoli, Luana,Marini, Francesca,Santi, Claudio,Terlizzi, Raffaella

, p. 3447 - 3458 (2007/10/03)

Se-Phenyl selenocarboxylates have been conveniently prepared from (phenylseleno)acetylenes by treatment with p-toluenesulfonic acid monohydrate in dichloromethane. This easy conversion is compatible with a broad range of oxygen- and nitrogen-containing functional groups. The Se-phenyl selenocarboxylates were easily converted into the corresponding esters and amides. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Psychoactive propargylamine derivatives used in the treatment of anxiety, psychotic states or aggression

-

, (2008/06/13)

Propargylamine derivatives having the general formula: STR1 wherein R is a hydrogen atom, an unsubstituted phenyl group or a phenyl group substituted with halogen, trifluoromethyl, loweralkoxy, nitro, cyano, amido or N,N-diloweralkylamido, R1,

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