144216-11-5

Basic information

• Product Name: 6,7-Difluoro-4-oxo-1H-quinoline-3-carboxylic acid
• Synonyms: 6,7-Difluoro-4-oxo-1H-quinoline-3-carboxylic acid
• CAS NO: 144216-11-5
• Molecular Formula: C₁₀H₅F₂NO₃
• Molecular Weight: 225.1484064
• Mol File: 144216-11-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6,7-Difluoro-4-oxo-1H-quinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Difluoro-4-oxo-1H-quinoline-3-carboxylic acid(144216-11-5)
• EPA Substance Registry System: 6,7-Difluoro-4-oxo-1H-quinoline-3-carboxylic acid(144216-11-5)

Safety Data

• Hazardous Substances Data: 144216-11-5(Hazardous Substances Data)

Upstream product

• 121873-01-6 6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 3863-11-4 3,4-difluoroaniline 
• 142354-87-8 diethyl 2-[(3,4-difluorophenylamino)methylene]malonate 
• 251986-58-0 4,5-dimethoxycarbonyl-1-(3',4'-difluorophenyl)-1H-pyrrole-2,3-dione 
• 251986-70-6 6,7-difluoro-4-oxo-1,4-dihydro-quinoline-2,3-dicarboxylic acid 3-methyl ester 
• 251986-64-8 6,7-difluoro-4-oxo-1,4-dihydro-quinoline-2,3-dicarboxylic acid dimethyl ester 
• 144216-15-9 methyl 6,7-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylate 
• 251986-50-2 methyl 3-carbomethoxy-3-(3',4'-difluorophenyl)amino-2-propenoate 
• 111760-35-1 ethyl 6,7-difluoro-4-hydroxy-3-quinolinecarboxylate 

Downstream Products

• 1134061-62-3 6-fluoro-4-hydroxy-7-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}quinoline-3-carboxylic acid 
• 420830-23-5 6-fluoro-7-(N-morpholinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 

Relevant articles and documents

HAPTENS AND IMMUNOREACTIVE AGENTS AND USE THEREOF FOR PRODUCING FAMILY ANTIBODIES AND IMMUNOASSAYS FOR QUINOLONES

The invention relates to haptens, immunogens and secondary immunoreactive agents, to the use thereof for producing wide-spectrum antibodies against quinolone-type antibiotics, to the application thereof to immunochemical analysis techniques, and to a kit enabling the detection of said antibiotics in biological samples from food products of animal origin.

6,7-Difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid, a newly designed fluorescence enhancement-type derivatizing reagent for amino compounds

A novel fluorescence enhancement-type derivatizing reagent for amino compounds, 6,7-difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid (FMQC), was developed. FMQC reacts with aliphatic primary amino compounds to afford strong fluorescent derivatives having high photo-and thermo-stabilities. The FMQC derivatives of amino compounds showed 12-159 times higher fluorescence quantum efficiencies than those of FMQC in aqueous and polar organic media. Additionally, the absorption and fluorescence emission wavelength of the derivatives are red-shifted from those of FMQC. These differences in the fluorescence properties between FMQC and the fluorescent derivative enabled the simple and highly sensitive determination of amino compounds without removing any excess unreacted FMQC by using a simple spectrofluorometer as well as HPLC.

4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS

The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.

Synthesis of fluoro-4-hydroxyquinoline-3-carboxylic acids by the Gould-Jacobs reaction

The synthesis of several fluoro-4-hydroxyquinoline-3-carboxylic acids by the Gould-Jacobs reaction is presented. These quinolines are important intermediates for the preparation of antibacterial fluoroquinolones.

A synthesis of 4-quinolone-3-carboxylic acids via pyrolysis of N- aryldioxopyrrolines

A synthesis of 4-quinolone-3-carboxylic acids (8) was achieved by pyrolysis of 4,5-dimethoxycarbonyl-1-aryl-1H-pyrrole-2,3-diones (3) followed by selective demethoxycarbonylation of the resulting 2,3-dimethoxycarbonyl-4- quinolones (4) in excellent overall yields.

Tautomerism and acidity in 4-quinolone-3-carboxylic acid derivatives

Prototropic tautomerism in 4-quinolone-3-carboxylic acid derivatives has been studied with particular emphasis on the influence of the ring substituents on the equilibrium. The techniques used include UV, 1H-NMR, 13C-NMR (solution and 13C-NMR CP/MAS (solid state) and semiempirical and ab initio calculations. The pKa values of some quinolone derivatives have been determined and correlated with data obtained from semiempirical methods.