Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-Benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives
Following the discovery of a new series of 1-benzyl-4-[2-(N-benzoyl-N- methylamino)ethyl]piperidine (2) derivatives with a potent anti- acetylcholinesterase (anti-AChE) activity, we extended the structure-activity relationships (SAR) to rigid analogues (4