Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-Benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives

DOI: 10.1021/jm00102a005

Source and publish data:

Journal of Medicinal Chemistry p. 4542 - 4548 (1992)

Update date:2022-08-05

Topics:

Authors:

Sugimoto

Tsuchiya

Sugumi Sugumi

Higurashi

Karibe Karibe

Iimura Iimura

Sasaki Sasaki

Araki Araki

Yamanishi

Yamatsu Yamatsu

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Article abstract of DOI:10.1021/jm00102a005

Following the discovery of a new series of 1-benzyl-4-[2-(N-benzoyl-N- methylamino)ethyl]piperidine (2) derivatives with a potent anti- acetylcholinesterase (anti-AChE) activity, we extended the structure-activity relationships (SAR) to rigid analogues (4

Full text of DOI:10.1021/jm00102a005

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