1443437-96-4Relevant articles and documents
Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents
Bell, Jessica L.,Haak, Andrew J.,Wade, Susan M.,Kirchhoff, Paul D.,Neubig, Richard R.,Larsen, Scott D.
, p. 3826 - 3832 (2013/07/25)
CCG-1423 (1) is a novel inhibitor of Rho/MKL1/SRF-mediated gene transcription that inhibits invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis. We recently reported the design and synthesis of conformationally restricted analogs (e.g