89250-34-0

Usage

Uses

Used in Chemical Synthesis:
3-(2-METHYL-1,3-THIAZOL-4-YL)ANILINE is used as a reagent for the preparation of N-aryltrifluoromethanesulfinimide derivatives. These derivatives are important intermediates in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(2-METHYL-1,3-THIAZOL-4-YL)ANILINE is used as a key building block for the development of novel therapeutic agents. Its unique structure and reactivity make it a valuable component in the design and synthesis of new drugs with potential applications in various therapeutic areas.
Used in Agrochemical Industry:
3-(2-METHYL-1,3-THIAZOL-4-YL)ANILINE is also utilized in the agrochemical industry for the synthesis of new pesticides and herbicides. Its ability to form stable and active derivatives makes it a promising candidate for the development of more effective and environmentally friendly agrochemicals.

InChI:InChI=1/C10H10N2S/c1-7-12-10(6-13-7)8-3-2-4-9(11)5-8/h2-6H,11H2,1H3

Upstream product

• 39541-91-8 2-methyl-4-(3-nitrophenyl)-thiazole 
• 2227-64-7 3'-nitro-2-bromoacetophenone 
• 99-03-6 1-(3-aminophenyl)ethanone 
• 72801-78-6 1-(3-formylaminophenyl)ethanone 
• 312925-73-8 N-(3-(2-methylthiazol-4-yl)phenyl)acetamide 
• 15473-81-1 3'-amino-2-bromoacetophenone hydrobromide 
• 62-55-5 thioacetamide 

Downstream Products

• 570431-14-0 (2-chloromethyl-6,7-diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine 
• 914931-04-7 (6,7-diethoxy-2-nitromethyl-2,3-dihydro-1H-cyclopenta[b]quinolin-9-yl)[3-(2-methylthiazol-4-yl)phenyl]amine 
• 460750-93-0 (2-chloromethyl-6,7-diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine hydrochloride 
• 460751-22-8 (6-ethoxy-7-isopropoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine hydrochloride 
• 1210461-20-3 C₁₁H₁₁N₃S₂ 
• 851288-86-3 2-chloro-N-(3-(2-methylthiazol-4-yl)phenyl)acetamide 
• 1443437-96-4 C₂₅H₂₁F₆N₃O₂S 
• 1314302-06-1 2-chloro-4-(methylsulfonyl)-N-(3-(2-methylthiazol-4-yl)phenyl)benzamide 
• 537021-19-5 2,4-dichloro-N-(3-(2-methylthiazol-4-yl)phenyl)benzamide 
• 1364083-21-5 1-[3-(2-methylthiazol-4-yl)phenyl]-2,3-dihydro-1H-imidazo[1,2-f]phenanthridin-4-ylium bromide 
• 1364083-17-9 1-[3-(2-methylthiazol-4-yl)phenyl]-1,2,3,12b-tetrahydroimidazo[1,2-f]phenanthridine 
• 960255-08-7 2-(3-(2-methylthiazol-4-yl)phenylamino)pyrimidin-4(3H)-one 

Relevant academic research and scientific papers

BIARYLAMIDE INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, R1a, R1b, R2, R3, R4a and R4b are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The present invention relates to 3-azabicyclo[3.1.0]hexane derivatives, which are useful as vanilloid receptor (VR) ligands, methods of treating diseases, conditions and/or disorders modulated by vanilloid receptors with them, and processes for preparing them.

Synthesis and anticancer activities of some thiazole derivatives

In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl)aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2- yl]amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.

1, 3, 4-BENZOTRIAZEPIN-2-ONE SALTS AND THEIR USE AS CCK RECEPTOR LIGANDS

This invention relates to pharmaceutically acceptable salts of compounds of formula (I) wherein: W is N or N+-O-; R2 is an optionally substituted C1 to C18 hydrocarbyl group wherein up to three C atoms may optionally be replaced by N, O and/or S atoms. R3 is -(CR11R12)m-X-(CR13R14)p-R9; m is 0, 1, 2, 3 or 4; p is 0, 1 or 2; X is a bond, -CR15=CR16-, -C≡C-, C(O)NH, NHC(O), C(O)NMe, NMeC(O), C(O)O, NHC(O)NH, NHC(O)O, OC(O)NH, NH, O, CO, SO2, SO2NH, C(O)NHNH, R9 is H ; C1 to C6 alkyl ; or phenyl, naphthyl, pyridyl, benzimidazolyl, indazolyl, quinolinyl, isoquinolinyl, tetrahydroisoquinolinyl, indolinyl, isoindolinyl, indolyl, isoindolyl or 2-pyridonyl substituted with -L-Q. R4 is an optionally substituted C1 to C18 hydrocarbyl group wherein up to three C atoms may optionally be replaced by N, O and/or S atoms ; and Such salts are useful, for example, for the treatment of gastrin related disorders.

Fructose 1,6-bisphosphatase inhibitors

The present invention relates to certain quinazoline compounds which have utility in the treatment of diabetes mellitus, hypercholesterolemia, hyperlipidemia, diabetic complications and cancer. The invention also relates to pharmaceutical compositions and

Anilinoquinazoline inhibitors of fructose 1,6-bisphosphatase bind at a novel allosteric site: Synthesis, in vitro characterization, and x-ray crystallography

The synthesis and in vitro structure-activity relationships (SAR) of a novel series of anilinoquinazolines as allosteric inhibitors of fructose-1,6-bisphosphatase (F16Bpase) are reported. The compounds have a different SAR as inhibitors of F16Bpase than a

SUBSTITUTED HETEROCYCLYL-PHENYLFORMAMIDINES AND SALTS THEREOF

Compounds of the formula STR1 wherein R is hydrogen or methyl;R 1 is straight or branched alkyl of 1 to 6 carbon atoms, hydroxy(alkyl of 1 to 6 carbon atoms), mono-or di-(alkoxy of 1 to 6 carbon atoms)(alkyl of 1 to 6 carbon atoms), (alkyl of 1 to 6 cabon atoms) thio(alkyl of 1 to 6 carbon atoms), cyano(alkyl of 1 to 6 carbon atoms), alkenyl, alkynyl, or cycloalkyl;R 2 is hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms or halogen; andX is pyrazol-3-yl, 1,2,4-triazol-3-yl, pyridin-2-yl, pyridin-3-yl, thiazol-4-yl, 2-methyl-thiazol-4-yl or 2-methylamino-thiazol-4-yl;tautomers thereof, and non-toxic, pharmacologiically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antiulcerogenics and gastric acid secretion inhibitors.