A synthesis of cyclo-2,3-diphospho-D-glycerate from D-mannitol
cyclo-2,3-Diphospho-D-glycerate (c-DPG) was synthesized from D-mannitol in seven steps on a gram-scale. Key feature of the synthetic route is the cyclization of methyl 2,3-diphospho-D-glycerate using dicyclohexylcarbodiimide. The preparation described makes the natural product c-DPG available on a larger scale for the first time.