Inhibition of Cryptosporidium parvum in vitro by 9-(alkylthio)acridine derivatives
The synthesis of several acridinic thioethers is described. Compounds prepared were tested in vitro as potential drugs against the opportunistic infection known as cryptosporidiosis. With a view to predict activity, the quantitative structure-activity relationships were investigated. Correlations between experimental data and either log P or pKa are discussed.
Khalifa, Latifa,Rosales, Maria-Jose,Mascaro, Carmen,Karolak-Wojciechowska, Janina,Bsiri, Nadia,Brouant, Pierre,Barbe, Jacques
p. 163 - 166
(2007/10/03)
Application of Phase-Transfer Catalysis in the Acridine Series; I. S-Alkylation and S-Acylation of Thioacridone and of some Halogenated Thioacridone Derivatives
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Vlassa, M.,Kezdi, M.,Goia, I.
p. 850 - 851
(2007/10/02)
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