- Environmentally-friendly diethyl sulfate production process,
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The invention belongs to the field of chemical synthesis, and specially relates to an environmentally-friendly diethyl sulfate production process, which comprises: carrying out a reaction on a diethylsulfate intermediate (ethyl hydrogen sulfate or a mixture containing ethyl hydrogen sulfate) and sulfate or hydrochloride for 4-12 h at a temperature of 60-130 DEG C to generate a mixture of diethylsulfate and disulfate, cooling the mixture, dissolving with water, separating to obtain a disulfate solution and a diethyl sulfate crude product, and refining the diethyl sulfate crude product to obtain diethyl sulfate. According to the process of the invention, the reactants cannot be carbonized in the reaction process, the waste acid difficultly recycled is not generated, the product quality ishigh, the industrial production is easy to realize, and the process is an environmentally-friendly diethyl sulfate production process.
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Paragraph 0031-0033
(2020/01/25)
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- OPHTHALMIC SOLUTIONS
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Disclosed are ophthalmic solutions such as packaging solutions for storing ophthalmic devices and lens care solutions for cleaning, disinfecting, rinsing and/or storing ophthalmic devices. The ophthalmic solutions contain at least a polymerization product obtained from a monomeric mixture comprising (a) a monomer bearing a center of permanent positive charge and (b) a non-ionic ethylenically unsaturated monomer, wherein the solution has an osmolality of at least about 200 mOsm/kg, and a pH of about 4 to about 9.
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- Synthesis and anti-influenza virus activity of 7-O-alkylated derivatives related to zanamivir
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A series of 7-alkyl ether derivatives related to zanamivir were synthesized using direct alkylation of the C-7 alcohol of sialic acid. Alkyl ether moiety of less than 12 carbons in length showed low nanomolar inhibitory activity against influenza A virus sialidase. Furthermore, their moiety improved influenza A virus plaque reduction activity compared to zanamivir. However, removal of the 8,9-diol of the 7-O-alkyl derivatives resulted in loss of antiviral potency. This result suggests that 8,9-diol must play an important role in binding with both influenza A and B virus sialidases.
- Honda, Takeshi,Masuda, Takeshi,Yoshida, Shuku,Arai, Masami,Kaneko, Satoru,Yamashita, Makoto
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p. 1925 - 1928
(2007/10/03)
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- REACTIONS OF DIMETHYL AND DIETHYL SULFATES WITH SULFUR TRIOXIDE
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The composition of the products from the reaction of sulfur trioxide with dimethyl and diethyl sulfates and also with diethyl ether was investigated by 1H NMR spectroscopy.In addition to the main reaction leading to the formation of dialkyl polysulfates, in the case of the ethyl derivatives the side reaction involving sulfonation of the alkyl group at the β position is observed.This explains the preferred use of dimethyl sulfate in the syntheses of diaryl sulfones.
- Andrashchuk, N. P.,Moskvichev, Yu. A.,Shapiro, Yu. E.,Shutova, I. V.,Timoshenko, G. N.,Belyaeva, S. S.
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p. 1075 - 1079
(2007/10/02)
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- Membrane stabilizing phenoxy-piperidine compounds and pharmaceutical compositions employing such compounds
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Compounds of the formula (I) STR1 optically active isomers thereof, and/or pharmaceutically acceptable acid addition salts thereof are disclosed, wherein R1 is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, n-butyl, 2-hydroxyethyl, 3-hydroxypropyl and 4-hydroxybutyl, and wherein R is selected from the group consisting of STR2 in which R2, R3 R4 and R5 are the same or different and are each independently selected from the group consisting of hydrogen and methyl. Pharmaceutical preparations employing such compounds and method of using such compounds are also disclosed.
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- Reactions of Group V Metal Compounds with Sulfur Trioxide
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Trialkylphosphines react with equimolar amounts of sulfuric trioxide to form the 1:1 adducts R3P(1+)-SO3(1-).Trialkylarsines and -stibines undergo sulfur trioxide insertion reaction across the metal-carbon bond to give the trisulfonates of the metal M(OSO2R)3 (M=As,Sb).The reactions of trialkyl phosphites, with sulfur trioxide yield trialkyl phosphonates, trialkyl thiophosates, dialkyl alkylphosphonates, dialkyl sulfates, and polymers which contain phosphorus atoms.The reactions of trialkoxyarsines and -stibines result in the insertion of sulfur trioxide across the metal-oxygen bond to form the alkoxymetal alkylsulfates (RO)3-nM(OSO3R)n (M=As,Sb; n=1,2,3) depending on the stoichiometric ratios of the reagents used.Pyrolysis of the metal sulfates gives dialkyl sulfates and undistillable residues containing the metals.
- Ando, Fumio,Koketsu, Jugo,Ishii, Yoshio
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p. 3495 - 3499
(2007/10/02)
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- Benzoic acids, their derivatives and process for preparing them
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Acyl-aminoalkyl-benzoic acid and derivates thereof show a blood sugar lowering effect upon oral administration and can be used as orally applicable hypoglycemiants.
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- Benz (c) fluoran compounds and recording sheet containing them
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Novel benz[c]fluoran compounds such as 2-phenylamino-8-diethylamino-benz[c]fluoran, 2-(2',4',6'-trimethylphenylamino)-8-diethylamino-benz[c]fluoran and N-[8-diethylaminobenz[c]fluoran-2-yl]-N-[6-diethylaminofluoran-2-yl]amine, which are useful as a coloring material for record material systems such as pressure-sensitive copying paper or heat-sensitive copying paper, wherein colored images formed by an electron-donoracceptor color-forming reaction between coloring material and acidic material.
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- Benzo-1,2,4-triazines
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Benzo-1,2,4-triazines-1,4-di-N-oxides substituted in the 3-position with a substituted amino group and optionally substituted in the benzo ring are antimicrobial agents. The compounds, of which 3-(N-acetoacetylamino)benzo-1,2,4-triazine-1,4-di-N-oxide is a typical embodiment, are prepared from the corresponding 2-aminobenzo-1,2,4-triazine-1,4-di-N-oxide through alkylation or acylation.
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- Chromogenic compounds and method for preparation thereof
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Chromogenic compounds for use in pressure sensitive recording sheets represented by the formula: SPC1 Are disclosed, wherein R1 and R2 are independently, hydrogen substituted or unsubstituted lower alkyl, aliphatic acyl, phenyl substituted aliphatic acyl, benzoyl, aralky, phenyl (the benzene nuclei of those substituents may be further substituted by chlorine, bromine, lower alkyl, lower alkoxy or nitro), allyl, allyl substituted by lower alkyl or phenyl, propargyl, or propargyl substituted by lower alkyl or a phenyl; R3 and R4 are independently lower alkyl, benzyl and phenyl (the benzene nuclei or those substiutents may be further substituted by chlorine, bromine, lower alkyl or lower alkoxy), either R1 or R2 being other than hydrogen when R3 and R4 are both ethyl groups.
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