- Total Syntheses and Configuration Assignments of JBIR-06 and Related Depsipeptides
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The first total syntheses of JBIR-06 and two analogous depsipeptides, 12-membered antimycin-class antibiotics, have been accomplished via Shiina macrolactonization. Comparison of the spectroscopic data of the synthesized compounds with those reported for
- Hamada, Chie,Usuki, Yoshinosuke,Takeuchi, Daiki,Ogawa, Hikaru,Abe, Ryota,Satoh, Tetsuya
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- A Br?nsted Acid Catalyzed Cascade Reaction for the Conversion of Indoles to α-(3-Indolyl) Ketones by Using 2-Benzyloxy Aldehydes
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A Br?nsted acid catalyzed, operationally simple, scalable route to several functionalized α-(3-indolyl) ketones has been developed and the long-standing regioisomeric issue has been eliminated by choosing appropriate carbonyls. A readily available and cheap bottle reagent was used as the catalyst. This protocol was also applicable to the synthesis of densely functionalized α-(3-pyrrolyl) ketones. A detailed mechanistic study confirmed the involvement of enolether as a reaction intermediate. Several postsynthetic modifications along with easy access to β-carboline, tryptamines, tryptophols, and spiro-indolenine proclaim the synthetic utility of this powerful building block. On the basis of this concept, functionalized carbazoles were constructed by a cascade annulation strategy.
- Banerjee, Ankush,Maji, Modhu Sudan
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p. 11521 - 11527
(2019/08/16)
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- An enantioselective approach to 3-substituted pyrrolidines: Asymmetric synthesis for pyrrolidine core of serotonin norepinephrine reuptake inhibitors (SNRIs)
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A novel and efficient synthetic approach to enantiopure 3-substituted pyrrolidine skeleton from readily available (S)-PMB glycidyl ether as a starting material and its application to the asymmetric synthesis of pyrrolidine core 1 of serotonin norepinephrine reuptake inhibitors (SNRIs) 2 and 3 are described. The synthesis utilizes the organocatalyzed asymmetric Michael addition reaction as key step.
- Garg, Yuvraj,Sharma, Pooja,Pandey, Satyendra Kumar
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supporting information
p. 3493 - 3495
(2017/10/06)
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- Synthesis of α-amino and α-alkoxy aldehydes via oxoammonium oxidation
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Oxoammonium oxidation (TEMPO, 1) of various optically active α-amino and α-alkoxy alcohols affords the corresponding aldehydes in good yield and high enantiomeric purity.
- Leanna,Sowin,Morton
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p. 5029 - 5032
(2007/10/02)
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