144491-18-9Relevant academic research and scientific papers
Total Syntheses and Configuration Assignments of JBIR-06 and Related Depsipeptides
Hamada, Chie,Usuki, Yoshinosuke,Takeuchi, Daiki,Ogawa, Hikaru,Abe, Ryota,Satoh, Tetsuya
, p. 965 - 968 (2019)
The first total syntheses of JBIR-06 and two analogous depsipeptides, 12-membered antimycin-class antibiotics, have been accomplished via Shiina macrolactonization. Comparison of the spectroscopic data of the synthesized compounds with those reported for
A Br?nsted Acid Catalyzed Cascade Reaction for the Conversion of Indoles to α-(3-Indolyl) Ketones by Using 2-Benzyloxy Aldehydes
Banerjee, Ankush,Maji, Modhu Sudan
supporting information, p. 11521 - 11527 (2019/08/16)
A Br?nsted acid catalyzed, operationally simple, scalable route to several functionalized α-(3-indolyl) ketones has been developed and the long-standing regioisomeric issue has been eliminated by choosing appropriate carbonyls. A readily available and cheap bottle reagent was used as the catalyst. This protocol was also applicable to the synthesis of densely functionalized α-(3-pyrrolyl) ketones. A detailed mechanistic study confirmed the involvement of enolether as a reaction intermediate. Several postsynthetic modifications along with easy access to β-carboline, tryptamines, tryptophols, and spiro-indolenine proclaim the synthetic utility of this powerful building block. On the basis of this concept, functionalized carbazoles were constructed by a cascade annulation strategy.
An enantioselective approach to 3-substituted pyrrolidines: Asymmetric synthesis for pyrrolidine core of serotonin norepinephrine reuptake inhibitors (SNRIs)
Garg, Yuvraj,Sharma, Pooja,Pandey, Satyendra Kumar
supporting information, p. 3493 - 3495 (2017/10/06)
A novel and efficient synthetic approach to enantiopure 3-substituted pyrrolidine skeleton from readily available (S)-PMB glycidyl ether as a starting material and its application to the asymmetric synthesis of pyrrolidine core 1 of serotonin norepinephrine reuptake inhibitors (SNRIs) 2 and 3 are described. The synthesis utilizes the organocatalyzed asymmetric Michael addition reaction as key step.
Synthesis of α-amino and α-alkoxy aldehydes via oxoammonium oxidation
Leanna,Sowin,Morton
, p. 5029 - 5032 (2007/10/02)
Oxoammonium oxidation (TEMPO, 1) of various optically active α-amino and α-alkoxy alcohols affords the corresponding aldehydes in good yield and high enantiomeric purity.
